Abstract: Objective To understand the levels of drug resistance and multi-drug resistance for the first-line anti-tubeculoais drugs in Zhejiang province, and to provide evidence for tuberculosis control. Methods The proportional method was used in drug sensitivity test according to the guidelines recommending by WHO. Results The total drug resistance rate was 30.6%,the initial and the acquired drug resistance rate was 26.6% and 52.3% respectively,and the multi-drug resistance rate was 7.6%. Conclusion The tuberculosis drug resistance was increasing in Zhejiang province,and the tuberculosis control departments should pay more attention to this situation.

Key words: Mycobacterum tuberculosis, Drug resistance,bacterial