Abstract: Objective To evaluate the treatment outcome and si de-effects of national fixed-dose compounds (2HRZ/4HR).Methods 81 new bacteriological positive pulmonary tuberculosis patients were divided r andomly into treatment group (42 cases) and control (39 cases) group.Results The sputum negative conversion rates at the 2nd month in the treatment and the control group were 82.5% and 65.7% respectively.And the rates at the end of the chemotherapy were 100.0% and 88.6% respectively.Chest ra diography showed remarkable improvement.The resolution of pulmonary lesions in t he treatment group and the control group accounted for 92.7% and 94.3% respectiv ely.The cavity closure rates were 63.2% in the treatment group and 62.5% in the control group.Two patients defaulted because of hepatic dysfunction in the t re atment group and 4 patients in the control’s.Conclusion Nation al fixed-dose compounds rifater/rifinah show excellent therapeutic efficacy,saf ety and compliance in antituberculous chemotherapy,which could be recommended fo r wider use in tuberculosis control in China.

Key words: Fixed-dose compounds, Pulmonary tuberculosis/drug th erapy