Abstract: ObjectiveTo investigate the short-term and long-term therapeutic effects of different chemotherapeutic regimens for silicosis patients with initial smear positive pulmonary tuberculosis in different stages. MethodsAccording to silicosis stages and lesions distribution, 218 initial treated smear-positive Silicotuberculosis patients were divided into four groups (A1, A2, B1, B2) and received different chemotherapeutic regimens. All patients were supervised to finish chemotherapy and then followed up for 5 years. The rates of sputum negative conversion and relapse were observed. ResultsAt the end of full treatment courses, the sputum negative conversion rates in all groups were 100%. During the five-year follow-up, the sputum re-positive rates in A1 group、A2 group、B1 group、B2 group were 14.3%, 3.8%, 11.4% and 4.7% respectively. ConclusionsThe chemotherapeutic regimen with 3HRZS(E)/6HRZ/9HRE fits to treat Silicotuberculosis in stageⅠ-Ⅱ.The chemotherapeutic regimen with 3HRZS(E)/9HRZ/12HRE fits to treat Silicotuberculosis in stage Ⅲ, and the long-term effect of this group's chemotherapy is satisfactory.

Key words: silicotuberculosis/drug therapy, clinical protocols