Abstract: ObjectiveTo provide reasonable evidence of chemotherapy for new patients with pulmonary tuberculosis based on analyzing the prevalence of primary drug-resistant patients hospitalized in different periods. MethodsWe divided patients hospitalized in different period into two groups: patients in group Ⅰ were hospitalized from 1986 to 1988, and patients in group Ⅱ hospitalized from 2004 to 2005. Primary drug resistance data was analyzed retrospectively in these patients. Results1) Primary drug resistant rate: the rate of primary drug resistance were 27.2%(25/92) in group Ⅰ and 39.6%(65/164) in group Ⅱ. There was significant statistical difference on the rate of primary drug resistance(χ²=4.00,P=0.045). 2)Primary multi-drug resistant rate: the rate of primary multi-drug resistance were 1.1%(1/92) in group Ⅰ and 15.9% (26/164) in group Ⅱ. There was significant statistical difference on the frequency of primary multi-drug resistance(χ²=13.57,P=0.000 23). ConclusionThe rate of primary drug resistant and MDR-TB among hospitalized patients showed an increasing trend. It showed that initial patients with pulmonary tuberculosis should be detected by culture and drug susceptible test to identify patients with drug resistant timely and received a reasonable regimen.

Key words: Tuberculosis,pulmonary, Drug resistance,bacterial