Abstract: Objective To analyze the drug resistance of Mycobacterium tuberculosis in 1992,1996,2000 and 2004 respectively. Method Absolute concentration method was carried out for Mycobacterium drug sensitivity in 8 anti-tuberculosis drugs. Results The rate of drug resistance to all drugs were 59.6%,76.3%,70.5% and 50.8% respectively;the rate of initial resistance were 51.9%,79.9%,70.4% and 40.4% respectively;acquired resistance rate were 76.8%,67.5%,70.8% and 77.2%.The rate of drug resistance to INH,RFP and SM were higher than that to other drugs,the rate of drug resistance to SR,HR,SHR,SRE,SHRE combination were higher. Conclusion The Results show that the drug resistance of mycobacterium is rather serious in hospitalized patients,and more attention should be paid to management and treatment for the tuberculosis patients.

Key words: Pulmonary tuberculosis/epidemiology, Drug resistance,germ, Inpatients