Abstract: Objective To research on the clinical symptom of pulmonary disease caused by Nontuberculosis Mycobacteria(NTM). Methods Bacteria type identifications have been performed with 4129 cases of positive culture which have been isolated in Guangzhou from 1998 to 2002. 66 cases in final diagnosis were pulmonary disease caused by NTM and the full data about it were analyzed. Results 40 of the 66 cases were infected with rapid growth Mycobacteria , 29 of which were M.abscessus , 7 were M.chelonae , 3 were M.smegmatis and 1 was M.fortuitum . 26 of the 66 cases were infected with slow growth mycobacteria, 18 of which were M.avium , 6 were M.intracellulare , 1 was M.xenopi and 1 M.marinum .There were 10 Mycobacterium mixed infection. 16 cases were discovered lately, 31 cases have suffered for 1 to 10 years, 11cases for 11 to 25 years and 8 cases for over 30 years. The main symptoms were cough, expectorate white phlegm, hemoptysis and fever, respectively. Thoracic cavity with X-ray Irradiation showed that 69.69 percent of it were damaged in the both sides, 21.21 percent in the right, only 4.54 percent in the left, and 4.54 percent of it without focus. 26 cases involved in thoracic cavity membrane, 7 of which occurred in gathering liquid, NTM showed highly original resistance to the anti-tuberculosis drugs, but the ratio of resistance to quinolones, macrolides and aminogiycosides was lower.Conclusion The clinical symptom of pulmonary disease caused by NTM is not characteristic and has a long progress. There is a inferior effect of therapy with routine anti-tuberculosis drugs.

Key words: Mycobacterium, NTM,pulmonary, Clinical,analyzed