Table of Content

10 April 2014, Volume 36 Issue 4

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Efficacy of cerebrospinal fluid lavage replacement in severe tuberculous hydrocephalus

WU Guo-de，ZHENG Ting，LI Xin，ZHANG Zhen-chang，CAI Hong-bin，GE Zhao-ming

Chinese Journal of Antituberculosis. 2014, 36(4):  225-231.  doi:10.3969/j.issn.1000-6621.2014.04.001

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Objective  To explore the effect of cerebrospinal fluid (CSF) lavage replacement in patients with severe tuberculous hydrocephalus and evaluate its feasibility and safety. Methods  Thirty-five patients diagnosed with severe tuberculosis hydrocephalus were performed with external ventricle drainage operation. Seventeen patients received treatment with cerebrospinal fluid lavage replacement were assigned as the treatment group, and 18 cases untreated were assigned as the control group. CSF results, imaging examination and clinical outcome of two groups were observed and compared. Side effects of the treatment group were also observed. All cases in both groups have been followed up for half a year. Results  Significant differences were found between the two groups in CSF examinations during 1, 3, and 6 months’ follow-up. CSF pressure were (170±22) mm H₂O,（185±21）mm H₂O,（182±23）mm H₂O in the treatment group and （202±22）mm H₂O,（211±24）mm H₂O,（188±21）mm H₂O in the control group, in which t=-3.329, t=-2.436, P＜0.05 when compared 1 and 3 months’results. WBC were（74±13）×10⁶/L, （58±13）×10⁶/L,（39±10）×10⁶/L in the treatment group and （115±16）×10⁶/L，（85±10）×10⁶/L，（55±12）×10⁶/L in the control group (t=-5.190, t=-5.173, t=-5.173，P<0.001). Protein content were （0.52±0.32）g/L,（1.00±0.41）g/L,（0.45±0.28）g/L in the treatment group and（0.89±0.45）g/L, （2.02±0.67）g/L,（0.75±0.45）g/L in the control group (t=-2.407，t=-3.247，t=-2.434, P<0.05). Glucose content were （2.47±0.58）mmol/L,（2.38±0.50）mmol/L,（2.56±0.52）mmol/L in the treatment group and （2.16±0.54）mmol/L,（1.95±0.47）mmol/L,（2.12±0.51）mmol/L in the control group (t=-2.468，t=-2.476，P<0.05 when compared 3 and 6 months). Chloride content were （119±15）mmol/L,（128±17）mmol/L,（129±16）mmol/L in the treatment group and （110±14）mmol/L,（115±18）mmol/L,（124±17）mmol/L in the control group (t=-2.441，P<0.05 compared 3 months). After 6 months of follow-up from leaving hospital, 6 cases in the treatment group were cured, 7 cases were effective and 4 cases died. In the contrast control group, 5 cases were cured, 6 cases were effective and 7 cases died. All patients in the treatment group were treated with the cerebrospinal fluid lavage replacement for 6.5 times, among which 3 cases were suffered from side effects including brief chills, transient fever and convulsions. All side effects disappeared after symptomatic treatment. Conclusion  Cerebrospinal fluid lavage replacement is an effective, simply practicable and safe treatment for severe tuberculous hydrocephalus. This treatment may reduce the mortality of severe tuberculous hydrocephalus and the further study is necessary.

Analysis on risk factors of drug resistance for pulmonary tuberculosis in Kashgar prefecture of Xinjiang Uygur Autonomous Region

JIANG Dao-bin, Reyangguli NUERMAIMAITI, Qimanguli WUSHOUER, HU Xin,WEN Shu,Rouzi MAIMAITI, LI Shuang

Chinese Journal of Antituberculosis. 2014, 36(4):  232-237.  doi:10.3969/j.issn.1000-6621.2014.04.002

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Objective  To analyze the risk factors associated with drug resistance of pulmonary tuberculosis(PTB) patients in Kashgar prefecture of Xinjiang Uygur Autonomous Region, and provide scientific evidence for DR-PTB control.  Methods  A total of 758 PTB patients hospitalized in TB Institute of Kashgar prefecture between 1 October 2012 and 1 October 2013 were recruited in this study, among them, 209 were identified as DR-PTB. Questionnaires were administered to 758 patients, 721 responded with the valid response rate of 95.12%. Logistic regression analysis were used to investigate the risk factors associated with DR-PTB.  Results  The multivariate analysis showed that PTB patients with longer duration of tuberculosis（OR=10.725，95%CI=5.903-17.326）,incomplete directly observed treatment(DOTS)（OR=9.080，95%CI=6.531-17.017）,poor patient compliance（OR=4.683，95%CI=1.935-9.523）,treatment interruption（OR=5.013，95%CI=2.526-9.026）, malnutrition（OR=3.959，95%CI=1.984-9.081），T₂DM（OR=5.002，95%CI=1.993-10.019） and tuberculous cavity（OR=2.528，95%CI=1.648-7.001）were significantly more likely to have drug resistant PTB.  Conclusion  According to the risk factors of DR-PTB above, we should take effective and targeted prevention measures.

Analysis on the treatment outcome of 175 multidrug-resistant pulmonary tuberculosis cases

DING Xiao-yan, XU Wei-guo, ZHU Li-mei, ZHOU Yang, SHAO Yan, SONG Hong-huan, PAN Hong-qiu, LING Su-ping, SUN Jian-sheng, WU Yun-liang, GU Xin-rong, LU Feng, LU Wei

Chinese Journal of Antituberculosis. 2014, 36(4):  238-243.  doi:10.3969/j.issn.1000-6621.2014.04.003

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Objective  To analysis the treatment outcome of multidrug-resistant tuberculosis (MDR-TB) cases in three cities (Xuzhou city, Nantong city and Zhenjiang city) of Jiangsu province.  Methods  one hundred and seventy-five multidrug-resistant tuberculosis (MDR-TB) cases were enrolled in this study from 1 January 2009 to 31 December 2010 in these three cities. Among 175 MDR-TB cases 133 were male and 42 were female. These patients aged from 19 years to 88 years with mean age (49.74±15.24) years. Treatment period lasted for 24 months (injection period of 6 months, intensive period of 18 months). Eighty seven MDR-TB patients were treated with standardized treatment regimen and 88 MDR-TB patients were treated with individualized regimen. During the treatment period, examinations of sputum smear, sputum culture, liver function, blood and urine routine tests, chest radiography and body mass were carried out for patient surveillance (monthly in injection period, once every two months in intensive period). DOTS managements were carried out throughout the treatment. Rate was used to describe categorical va-riables, Excel worksheet was used to establish database. SPSS 13.0 software was applied for statistical analysis and chi-square test was used for comparison between groups.   Results  Among 175 MDR-TB cases, 84 cases were cured, 11 completed the full treatment course with the treatment success rate 54.29% (95/175). 53 (30.29%) cases were treatment failure, among whom 18 cases stopped taking drugs because of adverse reactions and 35 cases were treatment failure (including 9 cases developed XDR-TB). 11 (6.29%) cases defaulted, 14 cases died and 2 cases transferred out. The treatment success rate was 63.64% (7/11) in new patients, and 62.65% (52/83) in relapse patients and 44.44% (36/81) in other previously treated patients. The difference of treatment success rate among the three groups was statistical significance (χ²=11.03, P=0.004). The treatment success rates were 51.72% (45/87) in patients with standardized treatment regimen and 56.82% (50/88) in patients with individua-lized regimen, and there was no significant difference between the two groups (χ²=0.46, P>0.05). There was a significance difference (χ²=55.73, P<0.001) of treatment outcome among patients with different sputum culture results at the end of 6th month. The highest treatment success rate was 73.73% (87/118) in the patients with ne-gative sputum culture at the end of 6th month.  Conclusion  The treatment of MDR-TB in project areas is effective, and it can provide reference for MDR-TB control work in Jiangsu province.

Effect evaluation of tuberculosis prevention and control intervention among floating population in Anhui province

YAO Song，FANG Xue-hui，CHEN Gen-wang，ZOU Zheng，SHI Si-jiu，ZHANG Ze-kun，LI Ling

Chinese Journal of Antituberculosis. 2014, 36(4):  244-247.  doi:10.3969/j.issn.1000-6621.2014.04.004

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Objective  To investigate the status of tuberculosis(TB) patient treatment and management among floating population in Anhui province, and to evaluate the effect of Global Fund (GF) interventions in patient’s treatment compliance improvement.  Methods  Data collection used structured questionnaire administered to mobile patients enrolled and completed TB treatment between October 2010 to October 2011 in all 5 GF areas (GF group) and 5 randomly selected non-GF areas (non-GF group) in Anhui province. A total of 229 patients (99.57%, 229/230) completed the survey. They consisted of 111 cases from GF group and 118 from non-GF group. Survey data entry and analysis utilized EpiData 3.1 and SPSS 13.0 statistical software. Main evaluation indicators included rate of missing doses, incidence of adverse reactions, times and type of doctor visits, and patients’ awareness about TB medication. Differences in these indicators among patients from GF versus non-GF groups were tested using Chi-square test and α=0.05 as cut point for refuse or accept null hypothesis.  Results The proportion of patient who had missed prescribed medications accounted for 17.12% (19) and 35.59% (42) in GF (111 in total) group and non-GF(118) group respectively and the difference was statistically significant (χ²＝9.99, P<0.05). Significant difference was also observed in the incidence of adverse reactions between the two groups, 31.82% (35/110) for GF group compared with 47.46% (56/118) for non-GF group (χ²＝5.81, P<0.05）. Follow-up visits happened to 93 patients (83.78%) in the GF group which was significantly higher than that in the non-GF group (71.79%,χ²＝4.72, P<0.05). And the composition of doctors who had performed the follow-up visit was also different. For GF group, doctors from county or township level accounted for 75.27% (70/93), while the same indicator for non-GF group was only 59.52% (50/84) (χ²=5.01,P<0.05). The proportion of GF patients who believed that medication can be stopped if symptoms disappeared after a period of treatment was also significantly lower than that of non-GF patients (3.60% versus 10.81%,χ²＝4.31, P<0.05).  Conclusion  After GF supported interventions, patients’ treatment compliance and correct medication awareness of TB treatment among mobile population in GF areas were significantly better than those of patients in non-GF areas and the incidence of adverse reactions was also lower in GF areas than in non-GF areas.

Study on the efficacy of BCG vaccine for intradermal injection

KANG Wan-li, LING Ying, XU Miao, ZHAO Ai-hua, DU Wei-xin, CHEN Ming, GAO Tie-jie, ZHANG Zhi-guo, HU Dai-yu, FENG Xian-hui, GUO Jing, ZHANG Hai-xia, HE Ju, LIU Guan, LI Hai-ying, WU Xin-yue, WANG Cui-z

Chinese Journal of Antituberculosis. 2014, 36(4):  248-252.  doi:10.3969/j.issn.1000-6621.2014.04.005

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Objective  To study the immune efficacy and the influencing factors of BCG. Methods Multi-center, no control, open, prospective cohort study was used to select the study population. The effect and influencing factors of BCG were studied for the baby (<3 months) or the children (<1 years old) PPD negative in 4 districts (city) in Beijing, Jiangsu and Chongqing. The qualified study population was 27 517.  Results  (1) The median of BCG scar was 4.50 mm, the quartile of BCG scar was 3.50-5.00 mm. The BCG scar <1 mm was 223(0.81%, 223/27 517) and ≥1 mm 27 294(99.19%, 27 294/27 517). (2)The median of PPD was 8.50 mm, the quartile was 6.50-11.00 mm. The positive reaction was 26 838(97.53%, 26 838/27 517) and the negative reaction 679(2.47%, 679/27 517). (3) The negative rate of PPD was lower in urban（2.28%，571/25 004）than rural hospitals（4.30%，108/2513）(χ²=38.487, P<0.001). The negative rate of PPD was higher in tertiary hospital（4.18%，199/4760）than others (χ²=119.464，P<0.001). The negative rate of PPD was lower in Beijing（0.53%，57/10 679） than others area （χ²=288.511, P<0.001）. (4) There was 19 cases adverse reaction in the study, the rate of adverse reaction of BCG was 6.90/10 000. The rate of adverse reaction of BCG was different in the three provinces (χ²=32.005, P<0.001). Conclusion  The effect of BCG may be related with urban-rural difference, hospital level, area, et al. The monitoring of BCG vaccine effect should be strengthened. The effect of BCG vaccine should be improved in order to control the tuberculous meningitis and TB.

Radiation efficiency assessment for a kind of upper room ultraviolet germicidal irradiation system

WANG Ji-chun，LU Kai，ZHAO Fei，CHEN Liang，WANG Min，ZHANG Ying，QIN Yu，JIAO Yi-lin，SONG Yu-dan, GENG Meng-Jie, ZHAO Yan-lin, HE Guang-xue

Chinese Journal of Antituberculosis. 2014, 36(4):  253-255.  doi:10.3969/j.issn.1000-6621.2014.04.006

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Objective  To evaluate the radiation efficiency of a kind of ultraviolet germicidal irradiation (UVGI) system at upper room.  Methods  In an simulation ward and clinic equipped with “SINOVO^TM constant indoor air sterilization system”, to measure the radiation intensity in the following points: 1.0 m ahead of the system, 0.5 m, 1.0 m, 1.5 m to the left and right side of the system, 4.8 m of the opposite wall, and upper and lower 5 cm and 10 cm of each points mentioned above, and also the facial radiation strength and dose of 1.7 m height people. The intensity over 10 μW/cm² is effective germicidal strength, and radiation doses of less than 0.2 μW/cm² is safe dose.  Results  The radiation intensity is 427 μW/cm² 1.0 m distance ahead of “SINOVO^TM constant indoor air sterilization system”, 56 μW/cm² and 58 μW/cm² in its left and right sides (1.5 m) close to the walls,179 μW/cm², 111 μW/cm² and 70 μW/cm² 1.5 m, 2.0 m ahead and 4.8 m at the opposite wall.  Conclusion Upper room UVGI system is a safe, efficient disinfection tool which could apply to infection control of respiratory infectious diseases, especially for tuberculosis.

Analysis of liver injury in 5981 pulmonary tuberculosis patients treated with FDC

ZHOU Lin, WANG Ni, LIU Er-yong, LAI Yu-ji, CHEN Ming-ting, HE Jin-ge, GENG Hong, ZHANG Lian-ying, YUAN Yan-li, YANG Shu-min

Chinese Journal of Antituberculosis. 2014, 36(4):  256-259.  doi:10.3969/j.issn.1000-6621.2014.04.007

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Objective  In order to provide evidence for developing policy on expansion of fixed-dose combination (FDC) anti-TB drugs in China, FDC-associated liver injuries were evaluated. Methods  In 2011 and 2012, five provinces, including Gansu, Hebei, Jilin, Sichuan and Shandong, were involved in the evaluation. In each province, one prefecture was selected as the study site. All new pulmonary tuberculosis (PTB) patients notified from 1 July to 31 December 2011 were recruited in the study and FDC was used for treatment. EpiData 3.1 software was used for data entry and validation, and SPSS 16.0 was used for statistical analysis. The following data or information were collected and analyzed: time of getting liver damage and extent of liver damage, correlations between clinical symptoms and laboratory abnormalities, methods for dealing with liver damage (such as adjustment of treatment regimen and its influence to treatment outcomes). The value of P<0.05 was regarded as statistically significant difference.  Results  A total of 5981 PTB patients were enrolled in this study and 14.4% (862/5981) of them got abnormal liver function during treatment with FDC, including 2.4% (145/5981) of enrolled patients had abnormal alanine aminotransferase, 4.0% (241/5981) of enrolled patients had abnormal total bilirubin and 11.9% (714/5981) of enrolled patients had abnormal direct bilirubin. Among the patients who got abnormal liver function, 56.1% (484/862) of them had moderate or severe liver damage and it occurred within 1 month of treatment in 57.2% (277/484) of patients. Ten point three percent (619/5981) of enrolled patients showed clinical symptoms of adverse reaction in digestive system. Data from the patients who had digestive reactions and abnormal liver function were compared and the results showed that: there was no significant difference between digestive reactions and abnormal DBIL (χ²=1.1382, P>0.05); however, there were significant difference between digestive reactions and TBIL (χ²=14.3116, P<0.05), digestive reactions and ALT (χ²=19.4849，P<0.0001). The treatment was adjusted in 23.1% (112/484) of patients who had moderate or severe liver damage, namely FDC was replaced by loose drugs.  Conclusion  During treatment with FDC, the attention should be paid to liver injury.Patients who got moderate or severe liver injury,FDC should be replaced by loose drugs.

Loop-mediated isothermal amplification assay for detection of Mycobacterium tuberculosis in clinical specimens: a systemtic review

YU Xia, MA Yi-feng, FU Yu-hong, LIU Guan, WANG Xiao-bo, HUANG Hai-rong

Chinese Journal of Antituberculosis. 2014, 36(4):  260-266.  doi:10.3969/j.issn.1000-6621.2014.04.008

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Objective  To evaluate the diagnostic accuracy of loop-mediated isothermal amplification (LAMP) in detecting Mycobacterium tuberculosis in clinical samples.  Methods A fully recursive literature search was conducted by searching PubMed, Embase, Web of Science，Cochrane Library, CNKI，Wanfang and VIP databases. QUADAS criteria were used to evaluate the quality of the included studies, and Meta-Disc software was used to analyze data collected from the included studies. Sensitivity, specificity and summary receiver operator characteristic curve （SROC）were chosen as the indicators to assess the diagnostic accuracy of every individual diagnostic test. Heterogeneity between the individual studies was analysed by Meta regression.  Results  A total of 16 articles which including 18 studies were enrolled in the assay. Meta-analysis showed that the pooled sensitivity of LAMP was 0.91（95%CI 0.90-0.93）, the pooled specificity was 0.97（95%CI 0.96-0.97）, the pooled diagnostic odds (DOR) was 283.02（95%CI 157.37-509.00），the area below SROC curve(AUC) was 0.9829.Meta regression analysis showed that the studies with result interpretation by UV light have 5.66(RDOR=5.66,95%CI：1.32-24.22, P=0.0225) RDOR  than the studies with result interpretation by naked eyes.  Conclusion  The conducted researches confirm that LAMP assay is a highly specific test for the detection of Mycobacterium tuberculosis from clinical samples and has a potential in improving the diagnostic accuracy of in detecting Mycobacterium tuberculosis.

Evaluation of the application of fluorescent microscopy on detection of acid-fast bacillus

DING Bei-chuan, WANG Nen-han, ZHANG Jie, HOU Ji-zeng, ZHAO Ping, FAN Guo-wang, LI Guo-hong, WANG Su-min, HONG Feng, Lv Shang-jun

Chinese Journal of Antituberculosis. 2014, 36(4):  267-273.  doi:10.3969/j.issn.1000-6621.2014.04.009

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Objective  To evaluate the application of fluorescent microscopy for detection of acid-fast bacilli (AFB). Methods  2157 clinical samples were collected from 5 clinics for pulmonary tuberculosis (PTB), and all samples were detected by fluorescent staining (FS) microscopy and Ziehl-Neelsen (Z-N) microscopy, 1245 samples were conducted sputum culture as golden standard. The sensitivity, specificity and Youden’s index (Youden’s index=(sensitivity+specificity)-1=1-(false negative rate+false positive rate)) of FS and Z-N were evaluated. All results were compaired by Chi-square test with SPSS 17.0 statistical software, and P<0.05 was set as the criteria of statistical significance.  Results The positive rate of FS was 10.8% (234/2157), and that of Z-N was 8.8% (190/2157), the difference was statistically significant between the two methods (χ²＝25.473, P<0.001). The positive rate detected by FS was 15.9% (179/1127) in the specimens of new cases, and that of Z-N was 13.2% (149/1127), the difference was also statistically significant (χ²＝18.000, P<0.001). Among the specimens tested by smear and culture, the positive rate of FS was 13.8% (172/1245) and the positive rate of L-J culture was 15.2% (189/1245), and and there was no significant difference (χ²＝2.173, P=0.140). Among the specimens of new cases tested by smear and culture, the positive rate of FS was 16.4% (128/781) and the positive rate of L-J culture was 19.7% (154/781), which was 20.3% higher than the FS, and the difference was statistically significant (χ²＝7.861, P<0.01). The sensitivity of FS was 60.3% (114/189), the specificity was 94.5% (998/1056), the false negative rate was 39.7% (75/189) and Youden’s index was 0.548; corresponding results of Z-N were 56.6% (107/189), 97.1% (1025/1056), 43.4% (82/189) and 0.537, respectively. Conclusion Compared with Z-N, FS microscopy has higher sensitivity and similar specificity. Meanwhile, FS microscopy improves work efficiency, reduces labor intensity, which is suitable for basic laboratories with heavy workload and human resources shortage.

The value of acid-fast staining in pathological diagnosis of tuberculosis

ZHANG Deng-cai, LIU Bin, ZHANG Li-hua, SHI Min, SU Qin-jun, YANG Yan-li, QIAN Zhen, HA Ying-di

Chinese Journal of Antituberculosis. 2014, 36(4):  274-278.  doi:10.3969/j.issn.1000-6621.2014.04.010

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Objective To investigate the value of acid-fast staining in pathological diagnosis of tuberculosis(TB). Methods  Nine hundred and fourteen TB cases (485 male, 429 female) with acid-fast staining admitted to our hospital from 2000 to 2012 were analyzed retrospectively. SPSS 20.0 software was used for statistical analysis. Statistical comparisons were performed usingχ² test, and P value less than 0.05 was considered statistical significant. Results  Among the 914 patients positive rate of acid-fast staining was 31.95% (292/914). The positive rates of endobronchial TB, intestinal TB were 48.24％(41/85),58.06％(18/31) respectively，which were higher than that of pulmonary TB (33.33%, 72/216) with statistical significant differences (χ²=5.777, P<0.05; χ²=7.159, P<0.05); while the positive rates of pleural TB, spinal TB and osteoarthral TB were 19.78％(18/91),16.52％(19/115),12.00％(6/50) respectively, which were lower than that of pulmonary TB, with statistical significant differences (χ²=5.676, P<0.05; χ²=10.640, P<0.05; χ²=8.916, P<0.05). The positive rates in male and female patients were 30.93% (150/485) and 33.10% (142/429) respectively, with no statistical significance difference（χ²=0.494，P＞0.05）. Conclusion  Acid-fast staining is still an effective method for the diagnosis of TB. The positive rate can be affected by the lesion site.

Analysis of drug resistance of 1119 Mycobacterium tuberculosis strains in Puyang

MA Bing-qian, SUN Jing-tao, LIU Hui-jun, ZHU Lin, LI Hong-wei

Chinese Journal of Antituberculosis. 2014, 36(4):  279-285.  doi:10.3969/j.issn.1000-6621.2014.04.011

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Objective  To understand the epidemic situation and features of drug resistance of smear positive pulmonary tuberculosis (TB) in Puyang city of He’nan province, and to provide reference for TB control and prevention. Methods  The sputum samples of 1291 smear positive PTB patients detected in TB control institutes in Puyang from 1 March 2010 to 28 February 2013 were collected and cultured, proportion method of tubercle bacillus drug sensitivity test (DST) was conducted to 6 anti-TB drugs (H, R, E, S, Ofx, Km). One thonsand one hundred and nineteen Mycobacterium tuberculosis strains (of 1017 new patients and 102 retreated cases) with culture positive results and DST results were treated as the study object, and the DST results were analyzed. Chi-square test was used for categorical data comparison, P<0.05 was considered as statistically significant. Results The overall drug resistant rate, monoresistance rate, polyresistance rate and multidrug-resistance (MDR) rate were 37.2% (416/1119), 24.3% (272/1119), 8.2% (92/1119) and 4.5% (50/1119) respectively. The overall drug resistance rate was 35.1% (357/1017) among new cases and 57.8% (59/102) among previously treated cases. There was significant difference between the two groups (χ²＝20.525, P<0.05). The drug resistance rates to 6 anti-TB drugs arranged in descending order were H (19.9%, 223/1119), S (19.5%, 218/1119), R (10.8%, 121/1119), Ofx (3.7%,14/1119), E (3.6%, 40/1119) and Km (1.4%, 16/1119). The monoresistance rate was 24.3% (247/1017) among new cases and 24.5% (25/102) among previously treated cases, and the difference was not statistical significant (χ²＝0.002, P>0.05). The polyresistance rate was 7.9% (80/1017) among new cases and 11.8% (12/102) among previously treated cases, there was no significant difference between the two groups (χ²＝1.867, P>0.05). MDR rate was 2.9% (30/1017) among new cases, which was significantly lower than that among previously treated cases (19.6%, 20/102) (χ²＝56.423, P=0.000). Conclusion  The drug resistance results of 1119 smear positive TB cases reflect the actual level of drug resistance in Puyang, which lay the foundation for TB control and prevention, especially drug resistant TB control and prevention, taking interventions in time and controlling the epidemic more effectively in future.

Laboratory examination and quality control of Mycobacterium

WU Long-zhang，LIU Yan-wen，ZHONG Bing-tang

Chinese Journal of Antituberculosis. 2014, 36(4):  286-289.  doi:10.3969/j.issn.1000-6621.2014.04.012

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The prevalence of tuberculosis has been rising in China, and therefore bacteriologic studies of mycobacteria become the major means of the epidemiological research as well as clinical diagnosis of tuberculosis. This article is focus on how to improve diagnostic accuracy and tests quality control in a clinical laboratory.Retrospective study on both mycobacteria epidemiological process and its clinical diagnosis in the Guangzhou Chest Hospital, in order to provide some information in this field. Laid some technical foundation of TB epidemiological investigation and its diagnosis and treatment.

Current situation of tuberculosis control in designated hospitals in China

WU Teng-yan, LIU Fei-ying

Chinese Journal of Antituberculosis. 2014, 36(4):  290-293.  doi:10.3969/j.issn.1000-6621.2014.04.013

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According to the National 12^th Five-year Plan on TB Control, the tuberculosis (TB) designated hospital model will be the direction in building the TB health service system in the near future in China. We did a literature review on the current status of TB control in designated hospitals which aimed to identify and analyze the main problems and to provide recommendations for better implementation of this TB control model in the designated hospitals.