The risk of tuberculosis infection with non-tumor necrosis factor-targeted drugs in the treatment of rheumatoid arthritis

doi:10.19982/j.issn.1000-6621.20220242

Abstract

Abstract:

Rheumatoid arthritis (RA) is a common chronic, inflammatory autoimmune disease. Over the years, the application of tumor necrosis factor inhibitors (TNFi) has brought epoch-making progress to the treatment of RA, but its adverse risk, especially the significantly increased incidence of active tuberculosis, has attracted more and more attention. Recently, non-tumor necrosis factor (TNF)-targeted drugs have achieved good efficacy in the treatment of RA, more and more studies have shown that it caused the risk of active tuberculosis is lower than that of TNFi. This article will discuss the risk of tuberculosis infection with non-TNF-targeted drugs in the treatment of RA,which helps determine drug options for RA patients with latent tuberculosis infection (LTBI) and RA patients in geographical regions with a high prevalence of tuberculosis.

Key words: Arthritis,rheumatoid, Tuberculosis, Antirheumatic agents

CLC Number:

R52
R593.22

Han Xu, Guan Shangqi, Shi Yinpeng, Mei Yifang. The risk of tuberculosis infection with non-tumor necrosis factor-targeted drugs in the treatment of rheumatoid arthritis[J]. Chinese Journal of Antituberculosis, 2022, 44(9): 966-972. doi: 10.19982/j.issn.1000-6621.20220242

Figures/Tables 1

References 79

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优先级别^a	治疗方案	推荐级别	证据等级
首选	异烟肼+利福喷丁,1次/周,持续3个月	强	中等
首选	利福平,1次/d,持续4个月	强	中等(HIV阴性)^b
首选	利福平+异烟肼,1次/d,持续3个月	有条件推荐	极低(HIV阴性)
		有条件推荐	低(HIV阳性)
备选	异烟肼,1次/d,持续6个月	强^c	中等(HIV阴性)
		有条件推荐	中等(HIV阴性)
备选	异烟肼,1次/d,持续9个月	有条件推荐	中等