Possible causes of infection after BCG vaccination

doi:10.3969/j.issn.1000-6621.2020.08.017

Abstract

Abstract:

Bacillus Calmette-Guérin (BCG) is an attenuated live bacterial vaccine used for prevention of tuberculosis. Although BCG is proven to be one of the safest vaccines, there are still some adverse reactions. The most severe complication is systemically disseminated BCG infection. Although incidence of BCG-related infections is low, the prognosis is poor and severe cases can be fatal. Therefore, strengthening the understanding of possible causes of BCG-related infections is important for improved BCG vaccination and clinical treatment of these infections.

Key words: Tuberculosis, pulmonary, BCG vaccine, Vaccination, Mycobacterium infections, Primary immunodeficiency disease, Mendelian susceptibility to mycobacterial disease

CHEN Ning, SUN Lin, SHEN A-dong, HE Qiu-shui. Possible causes of infection after BCG vaccination[J]. Chinese Journal of Antituberculosis, 2020, 42(8): 869-873. doi: 10.3969/j.issn.1000-6621.2020.08.017

Figures/Tables 1

References 57

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第一作者	发表	人群	卡介苗	MSMD	卡介苗感染	是否有患者	基因缺陷
参考文献	年份	人群	接种例数	患者例数	患者例数	来自同一家族	基因缺陷
Sasaki^[30]	2002	日本	6	6	6	否	IFN-γR1
Picard^[26]	2002	巴基斯坦、印度、沙特阿拉伯	11	13	11	是	IL-12B
Fieschi^[31]	2003	全球17个国家	27	41	18	是	IL-12Rβ1
Lichtenauer-Kaligis^[32]	2003	土耳其	11	11	11	是	IL-12Rβ1
Newport^[33]	2004	美国、英国、土耳其、突尼斯等	24	60	20	是	IFN-γR1
Chapgier^[34]	2006	德国	3	3	2	否	STAT1
Filipe-Santos^[35]	2006	法国、德国	1	3	0	否	NEMO
de Beaucoudrey^[36]	2010	全球30个国家	114	141	65	是	IL-12Rβ1
Sologuren^[37]	2011	葡萄牙、波兰、智利、西班牙	7	14	6	是	IFN-γR1
Bustamante^[38]	2011	法国	6	7	6	是	CYBB
Hambleton^[39]	2011	爱尔兰、意大利	3	3	3	否	IRF8
Bogunovic^[40]	2012	土耳其、伊朗	-	3	-	是	ISG15
Prando^[41]	2013	印度、伊朗、巴基斯坦、沙特阿拉伯、突尼斯	41	49	40	是	IL-12B
Kong^[42]	2013	波兰、法国	3	4	3	是	IFN-γR2
Kreins^[43]	2015	日本、土耳其、摩洛哥、伊朗、阿根廷	8	2	4	是	TYK2
Okada^[44]	2015	巴勒斯坦、智利、沙特阿拉伯	4	7	4	是	RORC
Eletto^[45]	2016	巴基斯坦	1	1	0	否	JAK1
Oleaga-Quintas^[46]	2018	土耳其、印度	3	3	3	是	IFN-γR2
Alodayani^[27]	2018	沙特阿拉伯	3	3	3	是	IL-12B
Kong^[28]	2018	摩洛哥、土耳其	3	3	3	是	SPPL2A
Martínez-Barricarte^[29]	2018	土耳其、伊朗	-	3	-	是	IL-12Rβ1、IL-23R