Application of whole genome sequencing in research of Mycobacterium tuberculosis

doi:10.3969/j.issn.1000-6621.2020.07.017

Abstract

Abstract:

Whole genome sequencing has been widely used in the research of Mycobacterium tuberculosis (M.tuberculosis), including classification of M.tuberculosis lineages or subspecies, differentiation of disease patterns, identification of putative source cases and super-spreaders, determination of the transmission chains and their directions, as well as prediction of drug resistance of M.tuberculosis and detection of microevolution of M.tuberculosis. Although the whole genome sequencing has played an important role in clinical and public health applications, many problems are still existed and should be resolved in future. Herein, the current research directions and achievements of whole genome sequencing are reviewed, and the future applications are prospected.

Key words: Mycobacterium tuberculosis, Genome-wide association study, High-throughput nucleotide sequencing, Molecular diagnostic techniques, Review

ZHANG Jie, REN Yi-xuan, PAN Li-ping, ZHANG Zong-de. Application of whole genome sequencing in research of Mycobacterium tuberculosis[J]. Chinese Journal of Antituberculosis, 2020, 42(7): 737-740. doi: 10.3969/j.issn.1000-6621.2020.07.017

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