Abstract: Objective To study the therapentic effect of short-course chemotherapy on various types of initial drug-resistant pulmonary tuberculosis patients,and to evaluate the impact of the initial drug-resistant on the TB control.Methods To review 334 new pulmonary tuberculosis cases with initial drug-resistance tested 1996-2001 in Beijing.All the 334 patients could be classified into four groups,groupⅠ:sensitive pulmonary tuberculosis patients;groupⅡ:resistant to 1-3 of INH,SM,EB;groupⅢ:RFP resistant or SE resistant;groupⅣ: multidrug-resistant (MDR-TB);and based on the treatment failure rate of each group,we calculated weighted failure rate for Beijing,Zhejiang,Henan districts.Results The treatment failure rate of groupⅡ (4.26%) was identical with that of groupⅠ (1.04%),and the treatment failure rate of groupⅢ,groupⅣ were different from that of groupⅠ (11.11%,30.00% versus 1.04%) statistically. Initial drug-resistance increased the failure rate by 0.83,1.76,5.92 percent respectively in Beijing,Zhejiang,Henan districts.Conclusions The influence of the initial drug-resistance on the treatment outcome mainly depended on the RFP resistant level,particularly multidrug-resistant level;The influence of that on local district depended on the height of RFP initial resistant, particularly that of multidrug-resistant.

Key words: Tuberculosis,pulmonary/prevention and control, initial drug-resistant