Chinese Journal of Antituberculosis ›› 2023, Vol. 45 ›› Issue (2): 172-180.doi: 10.19982/j.issn.1000-6621.20220274
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Yang Hong1, Ma Jinbao1, Ren Fei1(), Li Rong1, Wu Yanqin1, Zhang Yaohui2
Received:
2022-12-20
Online:
2023-02-10
Published:
2023-02-01
Contact:
Ren Fei
E-mail:doc.renfei@163.com
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CLC Number:
Yang Hong, Ma Jinbao, Ren Fei, Li Rong, Wu Yanqin, Zhang Yaohui. Analysis of clinical characteristics of 15 household contacts of patients with drug-resistant pulmonary tuberculosis who developed active pulmonary tuberculosis[J]. Chinese Journal of Antituberculosis, 2023, 45(2): 172-180. doi: 10.19982/j.issn.1000-6621.20220274
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患者编号 | 性别 | 年龄 (岁) | 与指示 病例关系 | 结核病 治疗史 | 接触场所 通风情况 | 卡介苗 接种史 | 接触到发病 时间间隔(月) |
---|---|---|---|---|---|---|---|
病例1 | 女性 | 52 | 妻子 | 无 | 不良 | 无 | 11.0 |
病例2 | 女性 | 31 | 妹妹 | 无 | 一般 | 有 | 9.0 |
病例3 | 男性 | 51 | 丈夫 | 无 | 不良 | 无 | 9.0 |
病例4 | 女性 | 33 | 妻子 | 无 | 不良 | 有 | 11.0 |
病例5 | 女性 | 56 | 母亲 | 无 | 不良 | 无 | 3.0 |
病例6 | 女性 | 43 | 妻子 | 无 | 一般 | 无 | 0.5 |
病例7 | 女性 | 45 | 母亲 | 无 | 一般 | 无 | 1.0 |
病例8 | 女性 | 24 | 女儿 | 无 | 不良 | 有 | 1.0 |
病例9 | 女性 | 31 | 女儿 | 无 | 不良 | 无 | 2.0 |
病例10 | 男性 | 32 | 女婿 | 无 | 不良 | 无 | 1.5 |
病例11 | 女性 | 30 | 儿媳 | 无 | 良好 | 有 | 1.0 |
病例12 | 女性 | 29 | 妻子 | 无 | 良好 | 有 | 0.5 |
病例13 | 男性 | 3 | 儿子 | 无 | 一般 | 有 | 7.0 |
病例14 | 女性 | 34 | 妻子 | 无 | 良好 | 有 | 6.0 |
病例15 | 男性 | 47 | 父亲 | 无 | 不良 | 无 | 12.0 |
临床特点 | 指示病例(15例) | 罹患病例(15例) | χ2值 | P值 | ||
---|---|---|---|---|---|---|
性别 | 4.821 | 0.028 | ||||
男性 | 10(66.7) | 4(26.7) | ||||
女性 | 5(33.3) | 11(73.3) | ||||
年龄组(岁) | 1.598 | 0.891 | ||||
0~14 | 1(6.7) | 1(6.7) | ||||
15~24 | 1(6.7) | 1(6.7) | ||||
25~54 | 10(66.7) | 12(80.0) | ||||
≥55 | 3(20.0) | 1(6.7) | ||||
与指示病例的关系 | - | - | ||||
父母 | - | 3(20.0) | ||||
子女 | - | 3(20.0) | ||||
配偶 | - | 6(40.0) | ||||
妹妹 | - | 1(6.7) | ||||
儿媳 | - | 1(6.7) | ||||
女婿 | - | 1(6.7) | ||||
抗结核治疗史 | 15.000 | <0.001 | ||||
有 | 10(66.7) | 0(0.0) | ||||
无 | 5(33.3) | 15(100.0) | ||||
接触到发病时间(月)a | - | - | ||||
0~1 | - | 2(13.3) | ||||
1~2 | - | 4(26.7) | ||||
2~6 | - | 2(13.3) | ||||
6~12 | - | 6(40.0) | ||||
≥12 | - | 1(6.7) | ||||
PPD皮肤试验 | - | - | ||||
未做 | - | 3(20.0) | ||||
阴性 | - | 1(6.7) | ||||
一般阳性 | - | 0(0.0) | ||||
中度阳性 | - | 2(13.3) | ||||
强阳性 | - | 9(60.0) | ||||
T-SPOT.TB检测结果 | - | - | ||||
阴性 | - | 3(20.0) | ||||
阳性 | - | 10(66.7) | ||||
未做 | - | 2(13.3) | ||||
痰涂片检查抗酸杆菌 | 11.620 | 0.009 | ||||
阴性 | 5(33.3) | 13(86.6) | ||||
阳性 | 4(26.7) | 1(6.7) | ||||
+ | 3(20.0) | 1(6.7) | ||||
++~++++ | 3(20.0) | 0(0.0) | ||||
痰结核分枝杆菌培养 | 9.130 | 0.003 | ||||
阴性 | 0(0.0) | 7(46.7) | ||||
阳性 | 15(100.0) | 8(53.3) | ||||
临床特点 | 指示病例(15例) | 罹患病例(15例) | χ2值 | P值 | ||
影像学检查病灶肺野数 | 6.000 | 0.014 | ||||
1~3 | 10(66.7) | 15(100.0) | ||||
4~6 | 5(33.3) | 0(0.0) | ||||
是否有空洞 | 3.394 | 0.065 | ||||
有 | 9(60.0) | 4(26.7) | ||||
无 | 6(40.0) | 11(73.3) | ||||
就诊原因 | - | - | ||||
因症就诊 | - | 7(46.7) | ||||
主动筛查 | - | 8(53.3) |
分类 | 指示病例 | 罹患病例 | ||
---|---|---|---|---|
例数 | 构成比(%) | 例数 | 构成比(%) | |
病原学结果 | ||||
阳性 | 15 | 100.0 | 9 | 60.0 |
阴性 | 0 | 0.0 | 6 | 40.0 |
表型药敏试验结果 | ||||
耐多药 | 11 | 73.3 | 8 | 53.3 |
单耐药 | 4 | 26.7 | 1 | 6.7 |
未知 | 0 | 0.0 | 6 | 40.0 |
痰分子药敏试验结果 | ||||
耐药 | - | - | 6 | 40.0 |
敏感 | - | - | 0 | 0.0 |
未做 | - | - | 9 | 60.0 |
与指示病例药敏试验结果是否一致 | ||||
是 | - | - | 9 | 60.0 |
未知 | - | - | 6 | 40.0 |
结核病类别 | ||||
肺结核 | 9 | 60.0 | 13 | 86.6 |
肺外结核 | 0 | 0.0 | 1 | 6.7 |
肺结核合并肺外结核 | 6 | 40.0 | 1 | 6.7 |
治疗结局 | ||||
治愈 | 7 | 46.6 | 11 | 73.4 |
强化期末细菌学阴转 | 4 | 26.7 | 2 | 13.3 |
失败 | 4 | 26.7 | 0 | 0.0 |
丢失 | 0 | 0.0 | 2 | 13.3 |
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