Research progress of exhaled volatile organic compounds on the diagnosis of pulmonary infectious diseases

doi:10.19982/j.issn.1000-6621.20210693

Abstract

Abstract:

Current diagnostic methods for pulmonary infectious diseases are usually invasive and require specific laboratories and technologies. Therefore, it is necessary to develop novel non-invasive diagnostic tools. The detection method based on exhaled volatile organic compounds (VOC) has shown the potential as an alternative tool for traditional diagnostic and can be used to identify various pathogens quickly and in real time. VOC is derived from multiple endogenous metabolism processes in an organism, including lipid oxidation, carbohydrate, and fatty acids catabolism. Gaseous metabolites and decomposition products from these processes are transported through the circulatory system and be discharged quickly via the lungs. Therefore, they may become potential non-invasive metabolic biomarkers for diagnosing and monitoring pulmonary infectious diseases. The principle and common techniques of VOC detection, the collection method, the research status and problems of VOC in pulmonary infectious diseases are reviewed, and the VOC analysis method based on exhalation is prospected in this paper.

Key words: Lung diseases, Tuberculosis,pulmonary, Diagnostic techniques,respiratory system, Chemistry,organic, Diagnosis,differential

CLC Number:

R563

WU Chao-ling, DENG Guo-fang, FU Liang, YUAN Xiao-liang. Research progress of exhaled volatile organic compounds on the diagnosis of pulmonary infectious diseases[J]. Chinese Journal of Antituberculosis, 2022, 44(5): 505-511. doi: 10.19982/j.issn.1000-6621.20210693

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