Research progress on the correlation of gut microbiota with and pulmonary tuberculosis based on the theory of exterior and interior of lung and large intestine

doi:10.19982/j.issn.1000-6621.20210582

Abstract

Abstract:

Pulmonary tuberculosis is a common respiratory infectious disease, and the disorder of gut microbiota is a common complication of it. The disorder of gut microbiota can aggravate the pathological damage of pulmonary tuberculosis. From the perspective of pathogenesis of Traditional Chinese Medicine, the relationship of them embodies the meridian theory, the body fluid theory and the movement theory of Qi. From the perspective of biological mechanism, gut microbiota can limit the progress of pulmonary tuberculosis by producing anti-tuberculosis metabolites through regulating the host innate immunity and adaptive immunity. The disorder of gut microbiota caused by pulmonary tuberculosis may be associated with blood circulation and lymphatic circulation, and the influence of anti-tuberculosis drug on gut microbiota may be related to the bactericidal properties of drugs. The related therapy of intestinal flora has a certain clinical value in the diagnosis and treatment of pulmonary tuberculosis. The intestinal flora can be adjusted by increasing intestinal probiotics, fecal bacteria transplantation, rational use of anti-tuberculosis drugs, improving dietary structure and so on, which has achieved the purpose of adjuvant treatment of pulmonary tuberculosis. In this paper, the author will review the previous literature.

Key words: Medicine, Chinese Traditional, Gastrointestinal tract, Bacteria, Tuberculosis,pulmonary

CLC Number:

R24
R521

FEI Wan-wan, LU Zhen-hui, HUANG Xing, LI Cui, ZHANG Hui-yong, JIANG Yu-wei. Research progress on the correlation of gut microbiota with and pulmonary tuberculosis based on the theory of exterior and interior of lung and large intestine[J]. Chinese Journal of Antituberculosis, 2022, 44(5): 500-504. doi: 10.19982/j.issn.1000-6621.20210582

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