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中国防痨杂志 ›› 2022, Vol. 44 ›› Issue (12): 1363-1368.doi: 10.19982/j.issn.1000-6621.20220312

• 综述 • 上一篇    下一篇


盛钢, 褚洪迁, 刘丁一, 孙照刚()   

  1. 首都医科大学附属北京胸科医院转化医学研究室/北京市结核病胸部肿瘤研究所耐药结核病研究北京市重点实验室,北京 101149
  • 收稿日期:2022-08-12 出版日期:2022-12-10 发布日期:2022-12-02
  • 通信作者: 孙照刚
  • 基金资助:

Progress in the identification of Mycobacterium tuberculosis antigenic proteins in clinical specimens

Sheng Gang, Chu Hongqian, Liu Dingyi, Sun Zhaogang()   

  1. Translational Medicine Center, Beijing Chest Hospital, Captial Medical University/Beijing Key Laboratory in Drug Resistant Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
  • Received:2022-08-12 Online:2022-12-10 Published:2022-12-02
  • Contact: Sun Zhaogang
  • Supported by:
    Special Scientific Research Project of Capital Health Development Funded by Beijing Municipal Health Commission(2022-1G-2161)



关键词: 分枝杆菌,结核, 抗原,免疫学, 生物学鉴定法, 综述文献(主题)


Tuberculosis (TB) is a serious respiratory disease caused by Mycobacterium tuberculosis (MTB) infection. The spread of TB is hidden, and it is difficult to prevent and control. The current rapid detection technology of TB has certain shortcomings and new diagnostic technology is urgently needed. Antigen detection technology of TB is widely applicable, simple, rapid and accurate. However, no target with good and stable detection effect has been found, and even for the same antigen target, the detection efficiency of different studies varies greatly. Therefore, we reviewed the detection status of antigenic proteins in various clinical specimens confirmed by different identification methods and experimental studies, to reconsider the status and content of MTB antigens in clinical specimens, and improve the method of antigen discovery and identification, so as to provide the theoretical reference for the development of diagnostic technology for tuberculosis antigens.

Key words: Mycobacterium tuberculosis, Antigen, immunology, Biological assay, Review literature as topic