中国防痨杂志 ›› 2022, Vol. 44 ›› Issue (9): 966-972.doi: 10.19982/j.issn.1000-6621.20220242
收稿日期:
2022-06-27
出版日期:
2022-09-10
发布日期:
2022-09-05
通信作者:
梅轶芳
E-mail:myfyxd@163.com
基金资助:
Han Xu, Guan Shangqi, Shi Yinpeng, Mei Yifang()
Received:
2022-06-27
Online:
2022-09-10
Published:
2022-09-05
Contact:
Mei Yifang
E-mail:myfyxd@163.com
Supported by:
摘要:
类风湿关节炎是一种常见的慢性、炎症性自身免疫性疾病,多年来肿瘤坏死因子抑制剂(tumour necrosis factor inhibitors,TNFi)的应用为类风湿关节炎的治疗带来了划时代的进步,但其导致的不良风险,尤其是引起活动性结核病的发病率明显增加,越来越引起关注。而近年来非肿瘤坏死因子靶向药物治疗类风湿关节炎取得了良好的疗效,且越来越多的研究表明其引起活动性结核病的风险低于TNFi。笔者将对非肿瘤坏死因子靶向药物在治疗类风湿关节炎中的结核病风险进行综述,有助于指导存在结核分枝杆菌潜伏感染(latent tuberculosis infection,LTBI)的类风湿关节炎患者和结核病高流行地区的类风湿关节炎患者的药物选择。
中图分类号:
韩旭, 关尚琪, 石银朋, 梅轶芳. 非肿瘤坏死因子靶向药物治疗类风湿关节炎的结核感染风险研究进展[J]. 中国防痨杂志, 2022, 44(9): 966-972. doi: 10.19982/j.issn.1000-6621.20220242
Han Xu, Guan Shangqi, Shi Yinpeng, Mei Yifang. The risk of tuberculosis infection with non-tumor necrosis factor-targeted drugs in the treatment of rheumatoid arthritis[J]. Chinese Journal of Antituberculosis, 2022, 44(9): 966-972. doi: 10.19982/j.issn.1000-6621.20220242
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