结核病患者外周血淋巴细胞亚群检测及临床应用专家共识

doi:10.3969/j.issn.1000-6621.2020.10.001

摘要/Abstract

摘要：

结核病(TB)的发生、发展及转归取决于入侵结核分枝杆菌(MTB)的数量、毒力及机体免疫抵抗力。通过流式细胞术分析TB患者外周血淋巴细胞亚群有助于评估患者的免疫状况、免疫功能和免疫平衡,为临床制定免疫干预措施、观察疗效及判断预后等方面提供实验室检测依据。本专家共识简要地介绍了我国临床常用的淋巴细胞亚群分析项目(包括百分比和绝对计数);提出了TB患者淋巴细胞亚群检测及结果正确判读的建议;简介了淋巴细胞亚群分析在TB患者临床诊疗中的用途,并对未来淋巴细胞亚群检测的发展前景进行了展望。

关键词: 结核, 淋巴细胞亚群, 流式细胞术, 免疫, 实验室技术和方法

Abstract:

The occurrence, development and prognosis of tuberculosis (TB) depend on the quantity and virulence of MTB and immune resistance. The analysis of lymphocyte subsets in peripheral blood of TB patients by flow cytometry can help to evaluate the immune status, immune function and immune balance of TB patients, and provide experimental basis for clinical development of immune intervention measures, observation of curative effect and judgment of prognosis. This expert consensus briefly introduces lymphocyte subsets analysis items (including percentage and absolute count) commonly used in clinic; puts forward the suggestions for the detection of lymphocyte subsets in TB patients and the correct interpretation of the results; introduces the use of lymphocyte subsets analysis in the clinical diagnosis and treatment of TB patients, and prospects the development of lymphocyte subsets detection in the future.

Key words: Tuberculosis, Lymphocyte subsets, Flow cytometry, Immunity, Laboratory techniques and procedures

《中国防痨杂志》编辑委员会. 结核病患者外周血淋巴细胞亚群检测及临床应用专家共识[J]. 中国防痨杂志, 2020, 42(10): 1009-1016. doi: 10.3969/j.issn.1000-6621.2020.10.001

Editorial Board of Chinese Journal of Antituberculosis. Expert consensus on detection and clinical application of peripheral blood lymphocyte subsets in patients with tuberculosis[J]. Chinese Journal of Antituberculosis, 2020, 42(10): 1009-1016. doi: 10.3969/j.issn.1000-6621.2020.10.001

图/表 1

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