Email Alert | RSS    帮助

中国防痨杂志 ›› 2020, Vol. 42 ›› Issue (8): 874-879.doi: 10.3969/j.issn.1000-6621.2020.08.018

• 综述 • 上一篇    下一篇

结核分枝杆菌糖代谢的研究进展

屈孟锦, 梁正敏, 王元智, 周向梅()   

  1. 100193 北京,中国农业大学动物医学院
  • 收稿日期:2020-04-18 出版日期:2020-08-10 发布日期:2020-08-10
  • 通信作者: 周向梅 E-mail:zhouxm@cau.edu.cn
  • 基金资助:
    国家自然科学基金(31873005)

Research progress of carbohydrate metabolism of Mycobacterium tuberculosis

QU Meng-jin, LIANG Zheng-min, WANG Yuan-zhi, ZHOU Xiang-mei()   

  1. College of Veterinary Medicine, Chinese Agricultural University, Beijing 100193, China
  • Received:2020-04-18 Online:2020-08-10 Published:2020-08-10
  • Contact: ZHOU Xiang-mei E-mail:zhouxm@cau.edu.cn

摘要:

人们普遍认为结核分枝杆菌(Mycobacterium tuberculosis,MTB)优先依靠脂质代谢来建立和维持慢性感染,但是MTB的代谢网络可以对多种碳底物同时进行分解代谢,代谢的多功能性已经日益被认为是一种重要的致病机制。糖代谢在MTB的发病机制中占据重要地位,完整的糖代谢对于维持MTB稳态起着重要作用。作者以MTB糖代谢为线索,就MTB对糖类的转运、生成及分解代谢过程中的功能酶进行梳理和分析,并且探讨了糖代谢协助MTB维持稳态的机制,以期望为新型抗结核药品的研发提供科学依据。

关键词: 分枝杆菌, 结核, 碳水化合物代谢, 代谢产物学, 研究, 综述

Abstract:

Mycobacterium tuberculosis (MTB) is generally believed to preferentially rely on lipid metabolism to both establish and maintain chronic infections. However, the metabolic network of MTB can simultaneously catabolize multiple carbon substrates. The versatility of metabolism has been increasingly considered as an important pathogenic mechanism. Carbohydrate metabolism occupies a significant position in the pathogenesis of MTB, and complete carbohydrate metabolism plays an important role in maintaining the steady state of MTB. Based on MTB carbohydrate metabolism as a clue, the author sorts out and analyzes the transport and generation of sugar in MTB as well as the functional enzymes during the catabolism process, and explores the mechanism of carbohydrate metabolism to assist MTB in maintaining the homeostasis, so as to provide scientific basis for the research and development of new anti-tuberculosis drugs.

Key words: Mycobacterium tuberculosis, Carbohydrate metabolism, Metabolomics, Research, Review