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中国防痨杂志 ›› 2020, Vol. 42 ›› Issue (5): 442-448.doi: 10.3969/j.issn.1000-6621.2020.05.006

• 专家笔谈 • 上一篇    下一篇

结核性脑膜炎实验室诊断现状与展望

李自慧, 张宗德()   

  1. 101149 首都医科大学附属北京胸科医院 北京市结核病胸部肿瘤研究所 耐药结核病研究北京市重点实验室
  • 收稿日期:2020-02-17 出版日期:2020-05-10 发布日期:2020-05-08
  • 通信作者: 张宗德 E-mail:zzd417@ccmu.edu.cn
  • 基金资助:
    国家自然科学基金(81702097);“十三五”国家科技重大专项(2017ZX10201301-004);“十三五”国家科技重大专项(2018ZX10731301-003-003);北京市医院管理局登峰人才计划(DFL20181601)

Current situation and prospect of laboratory diagnosis of tuberculous meningitis

LI Zi-hui, ZHANG Zong-de()   

  1. Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing 101149, China
  • Received:2020-02-17 Online:2020-05-10 Published:2020-05-08
  • Contact: ZHANG Zong-de E-mail:zzd417@ccmu.edu.cn

摘要:

结核性脑膜炎是一种最严重和常见的中枢神经系统结核病,快速确诊和及时治疗是改善患者预后和提高患者生存率的关键。但是,由于缺乏有效的检测手段,确诊结核性脑膜炎目前仍非常困难。作者针对结核性脑膜炎实验室诊断的现状、最新研究进展,以及所面临的问题和挑战进行论述和讨论,呼吁进一步通过合作加强结核性脑膜炎的实验室诊断研究。

关键词: 结核,脑膜, 实验室技术和方法, 早期诊断, 基于问题的学习, 研究进展

Abstract:

Tuberculous meningitis (TBM) is the most serious and common form of central nervous system tuberculosis. Rapid diagnosis and timely treatment are the key to improve the prognosis and survival rate of patients. However, the definite diagnosis of TBM is still extremely difficult due to the lack of effective detection methods. This article discussed the current situation, the latest progress as well as the problems and challenges of TBM laboratory diagnosis, and called for cooperation to further strengthen the research on laboratory diagnosis of TBM.

Key words: Tuberculosis,meningeal, Laboratory techniques and procedures, Early diagnosis, Problem-based learning, Research progress