2型糖尿病并发肺结核患者血清白介素-12和趋化因子配体1水平变化

doi:10.3969/j.issn.1000-6621.2017.12.005

中国防痨杂志 ›› 2017, Vol. 39 ›› Issue (12): 1278-1281.doi: 10.3969/j.issn.1000-6621.2017.12.005

2型糖尿病并发肺结核患者血清白介素-12和趋化因子配体1水平变化

陈海军, 李雨泽, 刘玉琴, 陈向丽, 于天甲, 吕和, 姜辉, 李殿忠

150086 哈尔滨,黑龙江省医院医学影像部(陈海军);黑龙江省传染病防治院(李雨泽、刘玉琴、于天甲、姜辉、李殿忠);
哈尔滨医科大学地方病控制中心[陈向丽(在读硕士研究生)];
哈尔滨医科大学附属第一医院临床营养科(吕和)

收稿日期:2017-05-07 修回日期:2018-01-10 出版日期:2017-12-10 发布日期:2018-01-11
通信作者: 姜辉,Email:jianghui7722@163.com;李殿忠,Email:lidianzhong2010@163.com
基金资助:
黑龙江省卫生和计划生育委员会科研项目(2012-432)

Association between serum levels of interleukin-12, Chemokine cytokines ligand 1 and occurrence of Type 2 diabetes mellitus complicated with pulmonary tuberculosis

CHEN Hai-jun, LI Yu-ze, LIU Yu-qin, CHEN Xiang-li, YU Tian-jia, LYU He, JIANG Hui, LI Dian-zhong

Department of Medical imaging, Heilongjiang Province Hospital, Harbin 150086, China

Received:2017-05-07 Revised:2018-01-10 Online:2017-12-10 Published:2018-01-11
Contact: JIANG Hui, Email:jianghui7722@163.com; LI Dian-zhong, Email:lidianzhong2010@163.com

摘要/Abstract

摘要： 目的了解2型糖尿病并发肺结核(type 2 diabetes mellitus complicated with pulmonary tuberculosis,T2DM-PTB)患者血清中炎症细胞因子白细胞介素-12(interleukin-12,IL-12)、趋化因子配体1(chemokine cytokines ligand 1,CCL1)水平的变化情况。方法选取2014年9月至2015年6月在黑龙江省传染病防治院就诊的T2DM-PTB患者40例(T2DM-PTB组),T2DM患者40例(T2DM组),以及体检科筛查出的健康人群40名(对照组)作为研究对象。收集研究对象人口学特征资料,并抽清晨空腹静脉血3～4 ml。使用酶联免疫吸附试验检测研究对象血清中IL-12和CCL1的水平,并进行比较。结果对照组、T2DM组和T2DM-PTB组血清中IL-12水平分别为(9.87±2.75) μg/L、(11.25±1.99) μg/L、(13.33±3.67) μg/L,三组间比较差异有统计学意义(F=4.46,P<0.01);进一步的两两比较显示,T2DM组和T2DM-PTB组均高于对照组,T2DM-PTB组高于T2DM组,差异均有统计学意义(P值均＜0.05)。对照组、T2DM组和T2DM-PTB组血清中CCL1水平分别为(158.03±29.21) μg/L、(245.02±33.04) μg/L、(381.60±29.99) μg/L,三组间比较差异有统计学意义(F=267.90,P<0.01);进一步的两两比较显示,T2DM组和T2DM-PTB组均高于对照组,T2DM-PTB组高于T2DM组,差异均有统计学意义(LSD检验,P值均＜0.05)。结论 T2DM-PTB患者血清中IL-12和CCL1水平明显升高,对T2DM-PTB 的发病机制有提示作用。

关键词: 糖尿病,2型, 结核,肺, 共病现象, 白细胞介素12, 趋化因子CCL1, 数据说明,统计

Abstract: Objective To investigate the relationship between serum levels of interleukin-12 (IL-12), Chemokine cytokines ligand 1 (CCL1) and type 2 diabetes mellitus complicated with tuberculosis (T2DM-PTB). Methods From September 2014 to June 2015 in the Infectious Hospital of Heilongjiang Province, 40 cases of T2DM-PTB patients (group T2DM-PTB), 40 cases of T2DM patients (group T2DM), and 40 healthy people (control group) were selected as the research objects. The demographic characteristics of the subjects were collected. In addition, 3 to 4 ml venous blood was collected in the early morning. The serum levels of IL-12 and CCL1 were mea-sured by enzyme-linked immunosorbent assay and compared among groups. Results The serum concentrations of IL-12 in the control group, T2DM group and T2DM-PTB group were (9.87±2.75) μg/L, (11.25±1.99) μg/L and (13.33±3.67) μg/L, respectively. The difference among the three groups was significant (F=4.46, P<0.01). The serum levels of CCL1 in the control group, T2DM group and T2DM-PTB group were (158.03±29.21) μg/L, (245.02±33.04) μg/L and (381.60±29.99) μg/L, respectively. The difference among the three groups was significant (F=267.90, P<0.01). The serum levels of IL-12 and CCL1 in the T2DM and T2DM-PTB groups were significantly higher than that in the healthy control group, and the serum levels of IL-12 and CCL1 in the T2DM-PTB group was significantly higher compared with the T2DM group (P<0.05). Conclusion The serum levels of IL-12 and CCL1 in patients with T2DM-PTB were significantly increased, suggesting their roles in the pathogenesis of T2DM-PTB.

Key words: Diabetes mellitus, type 2, Tuberculosis, pulmonary, Comorbidity, Interleukin-12, Chemokine CCL1, Data interpretation, statistical

陈海军, 李雨泽, 刘玉琴, 陈向丽, 于天甲, 吕和, 姜辉, 李殿忠. 2型糖尿病并发肺结核患者血清白介素-12和趋化因子配体1水平变化[J]. 中国防痨杂志, 2017, 39(12): 1278-1281. doi: 10.3969/j.issn.1000-6621.2017.12.005

CHEN Hai-jun, LI Yu-ze, LIU Yu-qin, CHEN Xiang-li, YU Tian-jia, LYU He, JIANG Hui, LI Dian-zhong. Association between serum levels of interleukin-12, Chemokine cytokines ligand 1 and occurrence of Type 2 diabetes mellitus complicated with pulmonary tuberculosis[J]. Chinese Journal of Antituberculosis, 2017, 39(12): 1278-1281. doi: 10.3969/j.issn.1000-6621.2017.12.005

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2型糖尿病并发肺结核患者血清白介素-12和趋化因子配体1水平变化

Association between serum levels of interleukin-12, Chemokine cytokines ligand 1 and occurrence of Type 2 diabetes mellitus complicated with pulmonary tuberculosis

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