关键词: 结核, 肺/预防和控制, 普查, 监狱, 山东省

Abstract: Objective To explore the status of prevalence and spread of Tuberculosis（TB） and latent tuberculosis infection(LTBI) among people subjected to reeducation in certain jail in Shandong. MethodsThere were 324 inmates in the supervised section，10 inmates had been diagnosed as TB cases in the first quarter of 2008, other 314 inmates were screened with chest X-ray, HIV test, TST, ELISPOT test (T-SPOT.TB test), and epidemiological investigation was conducted for each person. For people who had the symptoms of coughing and sputum and TB cases, sputum or throat swabs were collected for culture, isolates were performed on identification and drug susceptibility test, Mycobacterium tuberculosis (MTB) was genotyped. ResultsHIV screening Results were negative for all 314 people screened; 3 sputum culture Results were positive with three strains of MTB isolated, strain A belonged to non-Beijing family, the genotype is unique 222325163333658, strain B and C were Beijing family and belonged to one cluster with the genotype 223325173533978; two active TB patients were found during the screening activities; concomitant TST and T-SPOT.TB Results were available for 312 subjects, 87 subjects(27.9%) tested positive by the T-SPOT.TB while 255 subjects (81.7%) tested positive by TST. The concordance between the two tests in this study was 42.3%（95%CI，36.8%-47.8%）. ConclusionsIn the supervised section of the jail, the rate of LTBI was 27.6% （86/312）regarding positive T-SPOT.TB result as the standard for defining LTBI; the period attack rate of TB was 3.70%(12/324); combining the traditional epidemiological investigation with molecular epidemiological technique, the Conclusion was that some cases were endogenous recrudescence and some were caused by recent MTB infection, there was partial spread of TB existed in this supervised section. Further measures on TB treatment, prevention and control should be adopted.

Key words: pulmonary tuberculosis/prevention & control, mass screening, prisons, Shandong province