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中国防痨杂志 ›› 2021, Vol. 43 ›› Issue (6): 619-624.doi: 10.3969/j.issn.1000-6621.2021.06.017

• 综述 • 上一篇    下一篇

含贝达喹啉方案治疗耐多药结核病的研究进展

廖伟明*, 付亮, 邓国防, 袁小亮()   

  1. 南方科技大学附属深圳市第三人民医院肺二科(付亮、邓国防)/赣南医学院第一附属医院呼吸内科(袁小亮)
  • 收稿日期:2021-01-19 出版日期:2021-06-10 发布日期:2021-06-02
  • 通信作者: 袁小亮 E-mail:yxlyyxs@126.com
  • 基金资助:
    江西省自然科学基金(20202BABL206116)

Research progress of bedaquiline for the treatment of multidrug-resistant tuberculosis

LIAO Wei-ming*, FU Liang, DENG Guo-fang, YUAN Xiao-liang()   

  1. *The First Clinical Medical College of Gannan Medical University, Jiangxi Province, Ganzhou 341000, China
  • Received:2021-01-19 Online:2021-06-10 Published:2021-06-02
  • Contact: YUAN Xiao-liang E-mail:yxlyyxs@126.com

摘要:

耐多药结核病的出现与蔓延成为世界卫生组织2035年终止结核病流行策略的一大阻碍。既往的研究显示,耐多药结核病采用二线抗结核药物治疗方案的治疗成功率较低,广泛耐药结核病的治疗成功率更低。因此,迫切需要开发新的抗结核药物。贝达喹啉是过去50年第一个批准用于治疗耐多药结核病的药品,其能明显提高耐多药结核病的治愈率,缩短治疗时间。作者对贝达喹啉治疗耐多药结核病的地位、临床研究进展及相关问题作一综述,以提高临床医生对贝达喹啉治疗耐多药结核病的认识。

关键词: 结核,抗多种药物性, 贝达喹啉, 临床方案, 研究

Abstract:

The emergence and spread of multidrug-resistant tuberculosis (MDR-TB) has become a major obstacle to the World Health Organization’s End TB Strategy by 2035. Some studies have shown that the treatment success rate of MDR-TB with second-line anti-TB drugs was lower, and it was even worse in the patients with extensive drug-resistant tuberculosis (XDR-TB). Therefore, there is an urgent need to develop new anti-tuberculosis drugs. Bedaquiline is the first drug approved for the treatment of MDR-TB in the past 50 years. It can significantly increase the cure rate of MDR-TB and shorten the treatment duration. In order to improve the clinical doctors’ understanding of bedaquiline on MDR-TB treatment, we wrote this paper by reviewing the status of bedaquiline in the treatment of MDR/XDR-TB, the clinical research progress and several relevant issues.

Key words: Tuberculosis,multidrug-resistant, Bedaquline, Clinical protocols, Research