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中国防痨杂志 ›› 2020, Vol. 42 ›› Issue (10): 1128-1133.doi: 10.3969/j.issn.1000-6621.2020.10.020

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卡介苗非特异性保护作用研究进展

陈柠, 孙琳, 申阿东, 何秋水()   

  1. 100069 北京,首都医科大学基础医学院病原生物学系[陈柠、何秋水(外籍教授)];首都医科大学附属北京儿童医院 北京市儿科研究所 儿科学国家重点学科 教育部儿科重大疾病研究重点实验室 国家呼吸系统疾病临床医学研究中心 儿童呼吸道感染性疾病研究北京市重点实验室(孙琳、申阿东);芬兰图尔库大学医学微生物和免疫学系(何秋水)
  • 收稿日期:2020-05-14 出版日期:2020-10-10 发布日期:2020-10-15
  • 通信作者: 何秋水 E-mail:qiuhe@utu.fi
  • 基金资助:
    北京市自然科学基金海淀原始创新联合基金前沿项目(19L2043);“十三五”重大传染病防治国家科技重大专项(2018ZX10715005-004-006);“十三五”重大传染病防治国家科技重大专项(2017ZX10202101-004-001)

Research progress on the non-specific protective effect of BCG

CHEN Ning, SUN Lin, SHEN A-dong, HE Qiu-shui*()   

  1. Department of Medical Microbiology, College of Basic Medicine, Capital Medical University,Beijing 100069, China (*Foreign Professor, Working in Department of Medical Microbiology and Immunology, University of Turku, Turku 20520, Finland)
  • Received:2020-05-14 Online:2020-10-10 Published:2020-10-15
  • Contact: HE Qiu-shui E-mail:qiuhe@utu.fi

摘要:

卡介苗除了用来预防结核病以外,也可以诱导非特异性保护作用。流行病学调查结果显示,卡介苗对其他病原体感染有一定的保护作用,可以有效提高儿童的存活率,并且有些已经通过随机临床试验得到验证。作者将对相关流行病学的研究结果和这种现象形成的机制进行总结。

关键词: 卡介苗, 免疫, 先天, 细菌感染, 冠状病毒感染, 非特异性保护作用, T细胞抗原受体特异性, 综述

Abstract:

In addition to the protection against tuberculosis, bacillus Calmette-Guérin (BCG) can induce non-specific protective effect (NSE). The results obtained by various epidemiological studies showed that BCG can provide certain protection against other pathogen infections and can effectively improve the survival rate of children. Some of those results had been verified by randomized clinical trials. In this review, the author will summarize the related epidemiological research results and the mechanisms of the NSE.

Key words: BCG vaccine, Immunity, innate, Bacterial infections, Coronavirus infections, Non-specific protective effect, T-cell antigen receptor specificity, Review