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中国防痨杂志 ›› 2019, Vol. 41 ›› Issue (2): 236-238.doi: 10.3969/j.issn.1000-6621.2019.02.021

• 短篇论著 • 上一篇    下一篇



  1. 211131 南京中医药大学附属南京医院 南京市第二医院 南京市公共卫生医疗中心结核二科
  • 收稿日期:2018-10-16 出版日期:2019-02-10 发布日期:2019-02-01
  • 通信作者: 茅惠娟

The expressions of peripheral blood interleukin-6 and C-reactive protein in patients with pulmonary tuberculosis complicated with type 2 diabetes mellitus

Jie CHEN,Hong-yang HAN,Zhi-song WU,Yi LIU,Nan-lan MA,Ya-ping ZHANG,Hui-juan MAO()   

  1. The Second Department of Tuberculosis, Nanjing Public Health Medical Center, the Second Hospital of Nanjing, Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing 211131, China
  • Received:2018-10-16 Online:2019-02-10 Published:2019-02-01
  • Contact: Hui-juan MAO


选择2018年1—6月在南京中医药大学附属南京医院(南京市第二医院 南京市公共卫生医疗中心)结核科就诊的并发2型糖尿病的肺结核(T2DM-PTB)患者186例,对其中符合入组标准的165例进行编号,用系统抽样法抽取其中的55例,作为T2DM-PTB组;对我院同期收治的与T2DM-PTB组性别、年龄范围匹配的815例单纯肺结核患者进行编号,用系统抽样法抽取其中的55例,作为对照组。检测两组患者血清中白细胞介素6(IL-6)、C反应蛋白(CRP)水平,以及痰抗酸杆菌涂片情况,计算病灶范围个数,进行统计学分析。结果显示,T2DM-PTB组血清中的IL-6、CRP水平和病灶范围的中位数(四分位数)[M(Q1,Q3)]分别为[21.2(21.2,44.4)ng/L、31.2(15.1,77.3)mg/L、4.0(3.3,6.0)个],均明显高于对照组[8.6(8.6,19.2)ng/L、13.5(4.5,37.4)mg/L、3.0(3.0,4.0)个],差异均有统计学意义(U值分别为3.78、3.45、2.45,P值分别为0.000、0.001、0.014);T2DM-PTB组痰抗酸杆菌涂片阳性等级数[M(Q1,Q3)]为1.5(0.0,5.8),高于对照组的0.0(0.0,2.0),但差异无统计学意义(U=1.74,P=0.083)。与单纯肺结核患者相比,T2DM-PTB患者的IL-6、CRP水平更高,病灶范围更广,提示T2DM-PTB患者炎症状态更加活跃。

关键词: 结核,肺, 糖尿病,2型, 共病现象, 白细胞介素6, C反应蛋白质, 判别分析


A total of 186 cases with T2DM-PTB who were admitted to the Tuberculosis Department of Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine (The Second Hospital of Nanjing, Nanjing Public Health Medical Center) from January 2018 to June 2018. One hundred and sixty-five patients who met the inclusion criteria were numbered, and 55 of them were selected as the T2DM-PTB group by systematic sampling method. In addition, 815 age-matched patients with pulmonary tuberculosis in our hospital were screened, and 55 of them were selected as the PTB group by systematic sampling method. The serum levels of IL-6 and CRP were tested, and examination of sputum smear for acid-fast bacilli was conducted. The numbers of lesions were counted for statistical analysis. The results showed that media (quartile) M(Q1,Q3) levels of serum IL-6, CRP, and the lung lesion rang of T2DM-PTB group were (21.2 (21.2,44.4) ng/L, 31.2 (15.1,77.3) mg/L, and 4.0 (3.3,6.0)) respectively, which were higher than those of PTB group (8.6 (8.6,19.2) ng/L, 13.5 (4.5,37.4) mg/L, and 3.0 (3.0,4.0); there were significant differences among the two groups (U=3.78, 3.45, and 2.45; P=0.000, 0.001, and 0.014). The media (quartile) M(Q1,Q3) number of sputum examination positive cases in the T2DM-PTB group was higher than that in the PTB group (1.5 (0.0,5.8) vs 0.0 (0.0,2.0)), but the difference was not statistically significant (U=1.74, P=0.083). In conclusion, compared with PTB patients, T2DM-PTB patients had higher levels of IL-6 and CRP and wider lung lesion ranges, suggesting more active inflammatory state in the patients suffering PTB and T2DM.

Key words: Tuberculosis,pulmonary, Diabetes mellitus,type 2, Comorbidity, Interleukin-6, C-reactive protein, Discriminant analysis