停止卡介苗复种后儿童青少年结核感染及发病的研究

摘要/Abstract

摘要： 目的　观察停止卡介苗 (BCG)复种后，儿童青少年结核感染及发病情况。方法 1998年分别对北京市房山区12岁学生 (停止BCG复种组)和北京市通州区12岁学生 (未停BCG复种组)行结核菌素 (PPD)试验，72小时测量PPD反应——凡硬结平均直径≥6mm者行胸部X线检查，发现肺部阴影者查痰抗酸菌等。然后，依据PPD反应强度及活动性肺结核病人检出情况测算结核感染率及患病率。结果停止BCG复种组与未停BCG复种组活动性肺结核病患病率分别为14.8/10万和18.6/10万 (P＞0.05)。结核感染率：以直径≥15mm为结核感染标准，分别为7.9%和19.6% (P＜0.05)；以直径≥20mm为标准，分别为3.9%和4.2% (P＞0.05)。由此可见，用于反映停止BCG复种组结核感染与发病的两项主要指标均不高于甚至低于未停BCG复种组。结论停止BCG复种后不会引起儿童青少年结核感染及发病的增加。同时可节省大量人力、物力和财力，更好实施其它有效的结核病控制措施。

关键词: 卡介苗接种, 结核/流行病学

Abstract: Objective To observe the infection and incidence of tuberculosis in children and youth after termination of BCG revaccination.Methods In 1998,PPD testing was conducted on 12 years old students from Fangshan district (BCG revaccination termination group) and Tongzhou district (BCG revaccination not termination group) of Beijing respectively,PPD reactions were measured at 72 hours,chest X ray examinations were performed on those with average diameter≥6mm indurations,acid fast bacillus detection was done for ones found exhibiting lung shadows and so on.Then,calculate tuberculosis infectious rate and morbidity according to PPD reaction intensity and finding of active tuberculosis patients.Results Morbidities of active pulmonary tuberculosis for BCG revaccination termination group and BCG revaccination not termination group were respectively 14.8/10⁵ and 18.6/10⁵ (P＞0.05).Tuberculosis infectious rates:when criterion as diameter ≥15mm 7.9% and 19.6% respectively (P＜0.005),and when criterion as diameter ≥20mm 3.9% and 4.2% respectively (P＞0.05).Therefore,the two indicators used as reflecting tuberculosis infection and onset after BCG revaccination termination were both not higher and even lower than the BCG revaccination group.Conclusion BCG revaccination termination don’t increase tuberculosis infection and initiation in children and adolescents.It can spare a large amount of manpower,material recourses,and financial capacity.

Key words: BCG vaccination, Tuberculosis/epidemiology

王化金,周长山,隗合平,阎久龄,李军,. 停止卡介苗复种后儿童青少年结核感染及发病的研究[J]. 中国防痨杂志, 2001, 23(2): 81-84.

WANG Hua jin,ZHOU Chang shan,WEI He ping,et al.. Investigation of infection and onset of tuberculosis in children and youth after termination of BCG vaccination[J]. Chinese Journal of Antituberculosis, 2001, 23(2): 81-84.

[1]	李淑艳，凌再芹，战云飞，王骏生，刘国利，杨效光，高大川. 1992—2011年山东省胸科医院住院儿童结核病患者临床流行病学分析[J]. 中国防痨杂志, 2014, 36(10): 905-910.
[2]	刘云霞刘言训张冰冰张洪梅薛付忠. 基于GWR模型的结核病空间流行病学研究[J]. 中国防痨杂志, 2013, 35(5): 343-346.
[3]	胡京坤. 新生儿接种卡介苗后卡痕与结核菌素反应之关系[J]. 中国防痨杂志, 2010, 32(8): 61-62.
[4]	李卫彬, 王予东, 侯琰, 陈忆红, 侯少杰, 赵清婷, 杜鹏程, 黄玉平. 开封市中小学入校新生结核菌素检查结果分析[J]. 中国防痨杂志, 2010, 32(8): 30-32.
[5]	梁煊. 白介素12受体β1缺陷病研究现况[J]. 中国防痨杂志, 2010, 32(2): 117-120.
[6]	来力伟, 刘政, 谭国超, 郭亚玲. 武警某部一起肺结核暴发流行的调查分析[J]. 中国防痨杂志, 2010, 32(1): 56-57.
[7]	王胜芬,王莉,杨立军,姜广路,夏辉,周杨,尚美,李强,赵冰,赵雁林. 某高级中学结核病爆发分离菌株的实验室鉴定[J]. 中国防痨杂志, 2009, 31(10): 573-578.
[8]	王仕昌,马欣,邓云峰,陶武威,刘志敏,郑建礼,庄吉金,王燕,张修磊,王海英. 结核病分子流行病学特征性研究[J]. 中国防痨杂志, 2008, 30(5): 408-410.
[9]	杨华林,白丽琼,陈有芳,成诗明,. 现代结核病控制模式的实施效果分析[J]. 中国防痨杂志, 2008, 30(3): 170-176.
[10]	高三友,杜长梅,马丽萍,王国杰,甄新安,孟澜涛,. 短化后复发肺结核的流行病学影响因素分析[J]. 中国防痨杂志, 2005, 27(3): 178-181.
[11]	陈祖府,雷承德,张永革,吴昌华,. 黔南州结核病传染源调查研究[J]. 中国防痨杂志, 2005, 27(1): 36-38.
[12]	张立兴,丁北川,屠德华,邢青,安燕生,. 北京结核菌株分子流行病学的研究[J]. 中国防痨杂志, 2001, 23(3): 141-147.
[13]	陈求扬,赵瑞英,曹光农,江秀文,徐有铭,林淑芳,. 福建省畲族人群结核病疫情调查分析[J]. 中国防痨杂志, 2001, 23(2): 112-113.

停止卡介苗复种后儿童青少年结核感染及发病的研究

Investigation of infection and onset of tuberculosis in children and youth after termination of BCG vaccination

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 13

编辑推荐

Metrics

本文评价

友情链接