脑脊液标志物在结核性脑膜炎诊断中的研究进展

doi:10.3969/j.issn.1000-6621.2021.12.017

摘要/Abstract

摘要：

结核性脑膜炎(tuberculous meningitis, TBM)患者早期的临床表现和影像学变化均不具有特异性,且缺乏有效的实验室诊断方法,致使其诊断异常困难。早期诊断TBM对于患者的及时治疗和改善预后至关重要。脑脊液(cerebrospinal fluid, CSF)中存在多种生物标志物,对TBM早期诊断具有一定的潜在价值。本文主要针对CSF中宿主诊断生物标志物用于TBM诊断的研究进展及挑战进行综述和讨论。

关键词: 结核,脑膜, 脑脊液, 宿主特异性, 生物标记, 诊断

Abstract:

The non-specific clinical manifestations and imaging changes of tuberculous meningitis (TBM) as well as the lack of efficient laboratory diagnostic approaches make the diagnosis of TBM extremely difficult. However, early diagnosis of TBM is extremely crucial for timely treatment and improvement of prognosis. There are many biomarkers in cerebrospinal fluid (CSF) which have potential value for early diagnosis of TBM. In this paper, we mainly reviewed and discussed the study progresses and challenges of using host biomarkers in CSF on TBM diagnosis.

Key words: Tuberculosis,meningeal, Cerebrospinal fluid, Host specificity, Biomarkers, Diagnosis

谌蒙蒙, 董静, 贾红彦, 张宗德, 潘丽萍. 脑脊液标志物在结核性脑膜炎诊断中的研究进展[J]. 中国防痨杂志, 2021, 43(12): 1327-1331. doi: 10.3969/j.issn.1000-6621.2021.12.017

CHEN Meng-meng, DONG Jing, JIA Hong-yan, ZHAGN Zong-de, PAN Li-ping. The research progress of biomarkers in cerebrospinal fluid for diagnosis of tuberculous meningitis[J]. Chinese Journal of Antituberculosis, 2021, 43(12): 1327-1331. doi: 10.3969/j.issn.1000-6621.2021.12.017

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