中国防痨杂志 ›› 2019, Vol. 41 ›› Issue (2): 233-235.doi: 10.3969/j.issn.1000-6621.2019.02.020
收稿日期:
2018-09-14
出版日期:
2019-02-10
发布日期:
2019-02-01
通信作者:
王志敏
E-mail:wangzhm@chgc.sh.cn
基金资助:
Bei-bei WU,Wei HUANG,Zhi-min WANG()
Received:
2018-09-14
Online:
2019-02-10
Published:
2019-02-01
Contact:
Zhi-min WANG
E-mail:wangzhm@chgc.sh.cn
摘要:
结核病由于其高死亡率和高发病率,是世界最严重的传染病之一。尽管人体具备强大的免疫系统,但结核分枝杆菌还是逃过了宿主的免疫,建立了一种持续感染的状态。由于抗结核药物研制发展缓慢,而结核分枝杆菌又在不断发生变化,结核病的防治一直都是人类面临的重大难题。近些年,由于间充质干细胞的免疫调节等特性被逐渐发现和证实,人们发现间充质干细胞有望给临床上治疗结核病带来新的希望。作者就间充质干细胞参与结核病治疗中的应用与问题进行了综述。
吴蓓蓓,黄薇,王志敏. 间充质干细胞在结核病治疗中的应用与问题[J]. 中国防痨杂志, 2019, 41(2): 233-235. doi: 10.3969/j.issn.1000-6621.2019.02.020
Bei-bei WU,Wei HUANG,Zhi-min WANG. The applications and problems of mesenchymal stem cells for the treatment of tuberculosis[J]. Chinese Journal of Antituberculosis, 2019, 41(2): 233-235. doi: 10.3969/j.issn.1000-6621.2019.02.020
[1] |
Zumla A, Nahid P, Cole ST . Advances in the development of new tuberculosis drugs and treatment regimens. Nat Rev Drug Discov, 2013,12(5):388-404.
doi: 10.1038/nrd4001 URL |
[2] |
Behr MA, Wilson MA, Gill WP , et al. Comparative genomics of BCG vaccines by whole-genome DNA microarray. Science, 1999,284(5419):1520-1523.
doi: 10.1126/science.284.5419.1520 URL |
[3] |
Orme IM . The Achilles heel of BCG. Tuberculosis (Edinb), 2010,90(6):329-332.
doi: 10.1016/j.tube.2010.06.002 URL |
[4] |
Zhang W, Zhang Y, Zheng H , et al. Genome sequencing and analysis of BCG vaccine strains. PLoS One, 2013,8(8):e71243.
doi: 10.1371/journal.pone.0071243 URL |
[5] |
Kupferschmidt K . Infectious disease. Taking a new shot at a TB vaccine. Science, 2011,334(6062):1488-1490.
doi: 10.1126/science.334.6062.1488 URL |
[6] |
Choi HG, Choi S, Back YW , et al. Mycobacterium tuberculosis Rv2882c protein induces activation of macrophages through TLR4 and exhibits vaccine potential. PLoS One, 2016,11(10):e0164458.
doi: 10.1371/journal.pone.0164458 URL |
[7] |
Chan J, Flynn J . The immunological aspects of latency in tuberculosis. Clin Immunol, 2004,110(1):2-12.
doi: 10.1016/S1521-6616(03)00210-9 URL |
[8] |
Flynn JL, Chan J . Immune evasion by Mycobacterium tuberculosis: living with the enemy. Curr Opin Immunol, 2003,15(4):450-455.
doi: 10.1016/S0952-7915(03)00075-X URL |
[9] |
Dominici M, Le Blanc K, Mueller I , et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement. Cytotherapy, 2006,8(4):315-317.
doi: 10.1080/14653240600855905 URL |
[10] |
Cuiffo BG, Karnoub AE . Mesenchymal stem cells in tumor development: emerging roles and concepts. Cell Adh Migr, 2012,6(3):220-230.
doi: 10.4161/cam.20875 URL |
[11] |
Mei SH, Haitsma JJ, Dos Santos CC , et al. Mesenchymal stem cells reduce inflammation while enhancing bacterial clea-rance and improving survival in sepsis. Am J Respir Crit Care Med, 2010,182(8):1047-1057.
doi: 10.1164/rccm.201001-0010OC URL |
[12] |
Malek TR, Ortega G, Chan C , et al. Role of Ly-6 in lymphocyte activation.Ⅱ. Induction of T cell activation by monoclonal anti-Ly-6 antibodies. J Exp Med, 1986,164(3):709-722.
doi: 10.1084/jem.164.3.709 URL |
[13] |
Raghuvanshi S, Sharma P, Singh S , et al. Mycobacterium tuberculosis evades host immunity by recruiting mesenchymal stem cells. Proc Natl Acad Sci USA, 2010,107(50):21653-21658.
doi: 10.1073/pnas.1007967107 URL |
[14] |
Parida SK, Poiret T, Zhenjiang L , et al. T-cell therapy: options for infectious diseases. Clin Infect Dis, 2015,61 Suppl 3: S217-224.
doi: 10.1093/cid/civ615 URL |
[15] |
Kim JS, Cha SH, Kim WS , et al. A novel therapeutic approach using mesenchymal stem cells to protect against Mycobacterium abscessus. Stem Cells, 2016,34(7):1957-1970.
doi: 10.1002/stem.2353 URL |
[16] | 宋瑞娟, 李锋, 卢水华 . 间充质干细胞辅助治疗耐多药结核病的研究进展. 中国防痨杂志, 2017,39(3):299-303. |
[17] |
Lee SC, Dickson DW, Liu W , et al. Induction of nitric oxide synthase activity in human astrocytes by interleukin-1 beta and interferon-gamma. J Neuroimmunol, 1993,46(1/2):19-24.
doi: 10.1016/0165-5728(93)90229-R URL |
[18] |
Cui R, Rekasi H, Hepner-Schefczyk M , et al. Human mesenchymal stromal/stem cells acquire immunostimulatory capacity upon cross-talk with natural killer cells and might improve the NK cell function of immunocompromised patients. Stem Cell Res Ther, 2016,7(1):88.
doi: 10.1186/s13287-016-0353-9 URL |
[19] | Herrmann M, Verrier S, Alini M . Strategies to stimulate mobilization and homing of endogenous stem and progenitor cells for bone tissue repair. Front Bioeng Biotechnol, 2015,3:79. |
[20] |
Abbott JD, Huang Y, Liu D , et al. Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury. Circulation, 2004,110(21):3300-3305.
doi: 10.1161/01.CIR.0000147780.30124.CF URL |
[21] |
Wang L, Li Y, Chen X , et al. MCP-1, MIP-1, IL-8 and ischemic cerebral tissue enhance human bone marrow stromal cell migration in interface culture. Hematology, 2002,7(2):113-117.
doi: 10.1080/10245330290028588 URL |
[22] |
Chen J, Li Y, Wang L , et al. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke, 2001,32(4):1005-1011.
doi: 10.1161/01.STR.32.4.1005 URL |
[23] |
Wang YY, Li XZ, Wang LB . Therapeutic implications of mesen-chymal stem cells in acute lung injury/acute respiratory distress syndrome. Stem Cell Res Ther, 2013,4(3):45.
doi: 10.1186/scrt193 URL |
[24] |
Nenasheva T, Nikolaev A, Diykanov D , et al. The introduction of mesenchymal stromal cells induces different immunological responses in the lungs of healthy and M.tuberculosis infected mice. PLoS One, 2017,12(6):e0178983.
doi: 10.1371/journal.pone.0178983 URL |
[25] |
Yudintceva NM, Bogolyubova IO, Muraviov AN , et al. Application of the allogenic mesenchymal stem cells in the therapy of the bladder tuberculosis. J Tissue Eng Regen Med, 2018,12(3):e1580-1593.
doi: 10.1002/term.v12.3 URL |
[26] |
Zuo W, Zhang T, Wu DZ , et al. p63 + Krt5 + distal airway stem cells are essential for lung regeneration . Nature, 2015,517(7536):616-620.
doi: 10.1038/nature13903 URL |
[27] |
Ma Q, Ma Y, Dai X , et al. Regeneration of functional alveoli by adult human SOX9 + airway basal cell transplantation . Protein Cell, 2018,9(3):267-282.
doi: 10.1007/s13238-018-0506-y |
[28] | Erokhin VV, Vasil’eva IA, Konopliannikov AG , et al. Systemic transplantation of autologous mesenchymal stem cells of the bone marrow in the treatment of patients with multidrug-resistant pulmonary tuberculosis. Probl Tuberk Bolezn Legk (Russian), 2008,( 10):3-6. |
[29] |
Skrahina A, Hurevich H, Zalutskaya A , et al. Alarming levels of drug-resistant tuberculosis in Belarus: results of a survey in Minsk. Eur Respir J, 2012,39(6):1425-1431.
doi: 10.1183/09031936.00145411 URL |
[30] |
Skrahin A, Ahmed RK, Ferrara G , et al. Autologous mesenchymal stromal cell infusion as adjunct treatment in patients with multidrug and extensively drug-resistant tuberculosis: an open-label phase 1 safety trial. Lancet Respir Med, 2014,2(2):108-122.
doi: 10.1016/S2213-2600(13)70234-0 URL |
[31] |
Zhang FB, Li L, Fang B , et al. Passage-restricted differentiation potential of mesenchymal stem cells into cardiomyocyte-like cells. Biochem Biophys Res Commun, 2005,336(3):784-792.
doi: 10.1016/j.bbrc.2005.08.177 URL |
[32] | Das B, Kashino SS, Pulu I , et al. CD271 + bone marrow mesen-chymal stem cells may provide a niche for dormant Mycobacte-rium tuberculosis. Sci Transl Med, 2013, 5(170): 170ra13. |
[33] |
Ramakrishnan L . Revisiting the role of the granuloma in tuberculosis. Nat Rev Immunol, 2012,12(5):352-366.
doi: 10.1038/nri3211 URL |
[1] | 刘晓莉, 雷丽梅, 郭周莉, 黄殷, 徐静, 赵霞, 王燕, 付莉. 结核病患者产生病耻感与领悟社会支持的相关性研究[J]. 中国防痨杂志, 2020, 42(9): 1002-1008. |
[2] | 中国防痨协会学术工作委员会《中国防痨杂志》编辑委员会. 抗结核药品固定剂量复合制剂的临床使用专家共识[J]. 中国防痨杂志, 2020, 42(9): 885-893. |
[3] | 靳鸿建. 我国县级结核病防治服务体系建设及防治工作亟需加强——一位老防痨工作者的意见和建议[J]. 中国防痨杂志, 2020, 42(9): 896-902. |
[4] | 张灿有, 夏辉, 成君. Ⅱ级生物安全柜在结核病实验室中的检测及报告要求[J]. 中国防痨杂志, 2020, 42(9): 903-909. |
[5] | 周林, 刘二勇, 孟庆琳, 陈明亭, 周新华, 高微微, 林明贵, 谢汝明. 《WS 288—2017 肺结核诊断》标准实施后肺结核诊断质量评估分析[J]. 中国防痨杂志, 2020, 42(9): 910-915. |
[6] | 刘二勇, 王前, 周林, 张国钦, 张修磊, 马永成, 杨枢敏, 王毳, 孟庆琳, 陈明亭, 林明贵, 屠德华. 我国部分地区病原学检测阴性肺结核诊断质量现状分析[J]. 中国防痨杂志, 2020, 42(9): 916-920. |
[7] | 孟庆琳, 李进岚, 林定文, 马永成, 侯双翼, 刘年强, 周林. 结核病防治从业人员对新的结核病标准相关知识知晓情况调查分析[J]. 中国防痨杂志, 2020, 42(9): 921-925. |
[8] | 王前, 周林, 刘二勇, 赵雁林, 李涛, 陈明亭, 杨丽佳, 王嘉. 我国县级结核病定点医疗机构结核病诊断能力现况调查研究[J]. 中国防痨杂志, 2020, 42(9): 926-930. |
[9] | 李婷, 何金戈, 苏茜, 李京, 李运葵, 高文凤, 高媛, 杨文. 结核菌素试验在四川省布拖县HIV感染/AIDS患者中筛查结核感染的价值[J]. 中国防痨杂志, 2020, 42(9): 931-936. |
[10] | 李运葵, 何金戈, 苏茜, 李婷, 李京, 高文凤, 杨文, 毛光玉. 结核病症状筛查在四川省布拖县HIV感染/AIDS患者中发现结核病患者的价值[J]. 中国防痨杂志, 2020, 42(9): 937-941. |
[11] | 苏茜, 夏勇, 逯嘉, 王丹霞, 何金戈. 2009—2018年四川省0~14 岁儿童肺结核流行特征分析[J]. 中国防痨杂志, 2020, 42(9): 942-947. |
[12] | 邓亚丽, 张天华, 刘卫平, 张宏伟, 马煜, 李鹏. 2014—2018年陕西省肺结核发病的时空聚集性分析[J]. 中国防痨杂志, 2020, 42(9): 948-955. |
[13] | 董晓, 赵珍, 刘年强, 王森路, 崔燕. 2009—2017年新疆维吾尔自治区老年肺结核发现特征分析[J]. 中国防痨杂志, 2020, 42(9): 956-961. |
[14] | 马廷龙, 韩毅, 程序, 刘志东. 超声抗结核药品电导入联合化疗对胸壁结核的疗效观察[J]. 中国防痨杂志, 2020, 42(9): 968-972. |
[15] | 南海, 张芸, 杨新婷, 段鸿飞. GeneXpert MTB/RIF对骨关节结核诊断价值的Meta分析[J]. 中国防痨杂志, 2020, 42(9): 973-980. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||