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中国防痨杂志 ›› 2018, Vol. 40 ›› Issue (12): 1355-1356.doi: 10.3969/j.issn.1000-6621.2018.12.022

• 学术争鸣 • 上一篇    下一篇

结核病病原学诊断评价方法探讨——与《结核病病原学分子诊断专家共识》作者商榷

杨蕾,王国治,卢锦标()   

  1. 102629 北京,中国食品药品检定研究院结核病疫苗室
  • 收稿日期:2018-09-28 出版日期:2018-12-10 发布日期:2018-12-10

Discussion on the evaluation methods of tuberculosis pathogens diagnosis—Comment on “Expert consensus on molecular diagnostics of tuberculosis pathogens

YANG Lei,WANG Guo-zhi,LU Jin-biao.()   

  1. Division of Tuberculosis Vaccines, National Institutes for Food and Drug Control, Beijing 102629,China
  • Received:2018-09-28 Online:2018-12-10 Published:2018-12-10

摘要:

最新发布的《结核病病原学分子诊断专家共识》有助于提高我国结核病临床诊断水平,但笔者对共识中“结核分枝杆菌复合群核酸检测与传统细菌学检测方法的比较”存在不同看法。目前,分子诊断试剂发展迅速,但不同检测试剂的敏感度和特异度有较大差异,应慎重评价分子诊断和细菌学诊断结果,共识中“任何一种分子生物学检测方法结果阳性、细菌学检测方法阴性时,应以分子生物学检测结果为准,视为结核分枝杆菌阳性”的结论难以成立。

关键词: 结核, 分子诊断技术, 细菌学技术, 结果评价(卫生保健), 异议和争论

Abstract:

The newly released “Expert consensus on molecular diagnostics of tuberculosis pathogens” contributes to improve the clinical diagnosis of tuberculosis in China. However, we have different views on the “Comparison of nucleic acid detection and traditional bacteriological detection of MTB complex”. At present the molecular diagnostic reagents are developing rapidly with certain differences in sensitivity and specificity. Therefore, the results of molecular diagnostic and bacteriological diagnostic should be interpreted carefully and it is difficult to draw the conclusion in the consensus that “If any molecular diagnostic result is positive while the bacteriological diagnostic result is negative, the final result should be subject to the molecular diagnostic method and regarded as MTB positive”.

Key words: Tuberculosis, Molecular diagnostic techniques, Bacteriological techniques, Outcome assessment (health care), Dissent and disputes