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中国防痨杂志 ›› 2018, Vol. 40 ›› Issue (3): 336-339.doi: 10.3969/j.issn.1000-6621.2018.03.024

• 短篇论著 • 上一篇    下一篇

369例无症状疑似肺结核患者的发现途径及临床特征分析

冯宗欣()   

  1. 457000 河南省濮阳市第五人民医院内二科
  • 收稿日期:2017-06-22 出版日期:2018-03-10 发布日期:2018-05-14
  • 通信作者: 冯宗欣 E-mail:fengzongxin01@163.com

Analysis of diagnosis and clinical characters of 369 suspected asymptomatic tuberculosis patients

Zong-xin FENG()   

  1. Department of 2nd Internal Medicine, the Fifth People’s Hospital in Puyang, Puyang 457000, China
  • Received:2017-06-22 Online:2018-03-10 Published:2018-05-14
  • Contact: Zong-xin FENG E-mail:fengzongxin01@163.com

摘要:

回顾性分析2011年1月至2016年1月在河南省濮阳市第五人民医院就诊登记的369例无症状疑似肺结核患者[其中疑似活动性肺结核267例(72.36%)、疑似非活动性肺结核102例(27.64%)]的发现途径及临床特征。其中男275例(74.53%)、女94例(25.47%);13~40岁者多见[68.83%(254/369)]。发现途径分别为入学体检[49.32%(182/369)]、因其他疾病行肺部检查[20.60%(76/369)]、职工体检[18.70%(69/369)],及羁押人员体检[11.38%(42/369)]。胸部CT扫描表现:单发小斑片状、树芽状、结节状阴影及结节状、点状钙化影占55.83%(206/369),单侧阴影占67.21%(248/369),上肺阴影占73.98%(273/369),斑片状阴影并空洞影有7.59%(28/369)。痰涂片抗酸杆菌(AFB)阳性患者占8.67%(32/369),涂阴培阴329例(89.16%),涂阳培阳32例(8.67%),涂阴培阳8例(2.17%),未发现非结核分枝杆菌及耐药菌。继发性肺结核占73.98%(273/369),无血行播散性肺结核。267例疑似活动性肺结核和26例[25.49%(26/102)]疑似非活动性肺结核患者在胸部CT复查后诊断为活动性结核病;该293例患者经规范的抗结核药物治疗(涂阴培阴者在知情同意情况下给予诊断性抗结核药物治疗),2个月末病灶明显吸收、空洞缩小率57.68%(169/293),涂阳阴转率82.35%(28/34),培阳阴转率77.50%(31/40);6个月末病灶完全吸收率47.78%(140/293)、空洞影闭合率100.00%(28/28),涂阳阴转率100.00%(34/34),培阳阴转率100.00%(40/40)。由此可见,无症状肺结核患者以体检时主动发现为主,胸部CT扫描在诊断与治疗后随访判断病灶有无好转方面有一定价值。

关键词: 结核,肺, 无症状感染, 体格检查, 疾病特征, 诊断技术和方法, 判别分析

Abstract:

Diagnosis and clinical characters of 369 suspected asymptomatic tuberculosis patients without any symptoms from the Fifth People’s Hospital in Puyang, Henan, between January 2011 and January 2016 were retrospectively analyzed. Of the 369 patients, 267 (72.36%) were suspected active TB, and 102 (27.64%) were suspected non-active TB; 275 were male (74.53%), 94 were female (25.47%); and mainly at the age of 13-40 years (68.83% (254/369)). The diagnosis methods were as follows: the physical examination after the entrance examination (49.32% (182/369)), the lung examination because of other diseases (20.60% (76/369)), the Staff Physical Examination (18.70% (69/369)), the Prisoners’ Physical Examination (11.38% (42/369)). According to CT scan, single small patchy, sprouts, nodular shadows and nodular, punctate calcification shadows were 55.83% (206/369), the unilateral shadow was 67.21% (248/369), the upper lung shadow was 73.98% (273/369), and the patchy and hole shadow was 7.59% (28/369). Patients with positive sputum smear acid-fast bacillus (AFB) accounted for 8.67% (32/369), smear-negative and culture-negative cases were 329 (89.16%), smear-positive and culture-positive cases were 32 (8.67%), and smear-negative and culture-positive cases were 8 (2.17%). Non-TB mycobacteria and drug-resistant bacteria were not found. Secondary TB accounted for 73.98% (273/369). There was no hematogenous disseminated pulmonary TB. The 267 patients diagnosed as suspected active TB and 26 (25.49% (26/102)) patients diagnosed as suspected non-active TB were diagnosed as active TB after a chest CT re-examination. The 293 patients were treated with normative anti-tuberculosis drugs, after 2 months, the lesions were clearly absorbed and the cavity reducton rate was 57.68% (169/293), and the conversion rate from smear-positive to smear-negative was 82.35% (28/34), the conversion rate from culture-positive to culture-negative was 77.50% (31/40); after 6 months, 47.78% (140/293) of the lesions were fully absorbed and the cavity closure rate was 100.00% (28/28), the conversion rate of smear-positive to smear-negative was 100.00% (34/34). with Asymptomatic pulmonary tuberculosis patientswere mainly diagnosed based on physical examination. The chest CT scan plays a certain part in diagnosing and judging whether the lesions changes for better or not after treatment.

Key words: Tuberculosis,pulmonary, Asymptomatic infections, Physical examination, Disease attri-butes, Diagnostic techniques and procedures, Discriminant analysis