白细胞介素2基因-330T/G和白细胞介素6基因-174G/C多态性与结核病易感性的Meta分析

doi:10.3969/j.issn.1000-6621.2018.03.010

摘要/Abstract

摘要：

目的分析白细胞介素2(IL-2)基因-330T/G和IL-6基因-174G/C多态性与结核病易感性的关系。方法在Medline、PubMed、EMBase、Web of Science、Elsevier Science Direct、万方数据库、中国知网(CNKI)和维普数据库中检索从1990年1月至2017年6月公开发表的关于IL-2和IL-6基因多态性与结核病易感性关系的中文和英文文献。初筛获得相关文献573篇,根据文献纳入和排除标准最终纳入文献12篇。应用Stata 12.0软件对各研究原始数据进行Meta分析。结果 IL-2基因-330T/G位点研究纳入文献共8篇,病例组971例,对照组1519名。Meta分析结果显示,欧洲人群中携带IL-2基因-330T等位基因者较携带-330G等位基因者患结核病风险低45%(T对G:OR=0.55;95%CI=0.31~0.98;P=0.042)。IL-6基因-174G/C位点纳入研究共9篇,病例组1445例,对照组1955名。Meta分析结果显示,美洲人群中携带IL-6基因-174G等位基因者患结核病风险是携带-174C等位基因者的1.65倍(G对C:OR=1.65;95%CI=1.28~2.13;P<0.01);亚洲人群中携带IL-6基因-174G等位基因者患结核病风险是携带-174C等位基因者的1.4倍(G对C:OR=1.40;95%CI=1.13~1.72;P=0.002)。结论 IL-2基因-330T/G位点等位基因T可能与欧洲人群结核病易感性风险降低相关;IL-6基因-174G/C位点等位基因G可能与美国人群和亚洲人群结核病易感性风险增加相关。

关键词: 结核, 白细胞介素2, 白细胞介素6, 多态性,单核苷酸, 疾病易感性, Meta分析

Abstract:

Objective To investigate the relationship between interleukin-2 (IL-2-330T/G) and interleukin-6 (IL-6-174G/C) gene polymorphisms and susceptibility of tuberculosis (TB).Methods Relevant English and Chinese publications were identified by a literature search in the PubMed, Medline, EMBase, Web of Science, Elsevier Science Direct, Wanfang Data, CNKI and Weipu databases from January 1990 to June 2017. Two investigators screened 573 articles, and 12 articles were finally included according to the inclusion and exclusion criteria. Meta-analysis was performed on the original data by using Stata 12.0.Results In all, eight studies containing 971 cases and 1519 controls were used to assess the potential influence of the IL-2-330T/G polymorphism with TB susceptibility. This Meta-analysis indicates that the TB risk in Europeans with gene T was 45% lower than those with gene G (T vs. G: OR=0.55, 95%CI=0.31-0.98, P=0.042). As for IL-6-174G/C, nine studies containing 1445 cases and 1955 controls were involved. The TB risk in Americans with gene G was 1.65 times higher than those with gene C (G vs. C: OR=1.65, 95%CI=1.28-2.13, P<0.01), and the TB risk in Asians with gene G was 1.4 times higher than those with gene C (G vs. C: OR=1.40, 95%CI=1.13-1.72, P=0.002).Conclusion This Meta-analysis indicates that the IL-2-330T/G polymorphism is associated with decrease in TB risk in Europeans, and IL-6-174G/C polymorphism is associated with increase in TB risk in Americans and Asians.

Key words: Tuberculosis, Interleukin-2, Interleukin-6, Polymorphism,single nucleotide, Disease susceptibility, Meta-analysis

李艳林,黎亮,唐秀芳,吴秀娟. 白细胞介素2基因-330T/G和白细胞介素6基因-174G/C多态性与结核病易感性的Meta分析[J]. 中国防痨杂志, 2018, 40(3): 263-268. doi: 10.3969/j.issn.1000-6621.2018.03.010

Yan-lin LI,Liang LI,Xiu-fang TANG,Xiu-juan WU. Association of IL-2-330T/G and IL-6-174G/C polymorphisms with tuberculosis susceptibility: a Meta-analysis[J]. Chinese Journal of Antituberculosis, 2018, 40(3): 263-268. doi: 10.3969/j.issn.1000-6621.2018.03.010

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地区	等位基因模型 (T对G)		纯合子模型 (TT对GG)		杂合子模型 (TG对GG)		显性模型 (TT+TG对GG)		隐性模型 (TT对TG+GG)
地区	OR(95%CI)值	P值	OR(95%CI)值	P值	OR(95%CI)值	P值	OR(95%CI)值	P值	OR(95%CI)值	P值
总体	0.75 (0.59~0.95)	0.019	0.57 (0.32~1.02)	0.056	0.97 (0.56~1.67)	0.902	0.77 (0.47~1.25)	0.290	0.62 (0.42~0.93)	0.020
亚洲	0.81 (0.60~1.10)	0.174	0.66 (0.28~1.54)	0.331	0.83 (0.32~2.16)	0.702	0.78 (0.32~1.91)	0.581	0.74 (0.50~1.10)	0.134
欧洲	0.55 (0.31~0.98)	0.042	0.36 (0.13~1.00)	0.049	1.08 (0.60~1.98)	0.791	0.66 (0.38~1.13)	0.127	0.36 (0.12~1.05)	0.061
美洲	1.02 (0.74~1.40)	0.927	1.13 (0.56~2.27)	0.728	1.23 (0.61~2.50)	0.566	1.18 (0.60~2.29)	0.634	0.96 (0.63~1.47)	0.857

地区	等位基因模型 (G对C)		纯合子模型 (GG对CC)		杂合子模型 (GC对GG)		显性模型 (GG+GC对CC)		隐性模型 (GG对GC+CC)
地区	OR(95%CI)值	P值	OR(95%CI)值	P值	OR(95%CI)值	P值	OR(95%CI)值	P值	OR(95%CI)值	P值
总体	1.40 (1.21~1.62)	<0.01	1.98 (1.36~2.87)	<0.01	1.46 (1.00~2.14)	0.049	1.75 (1.22~2.52)	0.002	1.44 (1.21~1.72)	<0.01
亚洲	1.40 (1.13~1.72)	0.002	2.15 (1.17~3.92)	0.013	1.51 (0.83~2.75)	0.179	1.85 (1.03~3.32)	0.040	1.43 (1.12~1.83)	0.005
欧洲	1.09 (0.79~1.50)	0.594	1.25 (0.62~2.52)	0.528	1.23 (0.60~2.53)	0.573	1.25 (0.64~2.46)	0.518	1.06 (0.70~1.61)	0.773
美洲	1.65 (1.28~2.13)	<0.01	2.64 (1.39~5.01)	0.003	1.63 (0.84~3.15)	0.149	2.20 (1.18~4.12)	0.014	1.76 (1.28~2.41)	<0.01