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中国防痨杂志 ›› 2022, Vol. 44 ›› Issue (2): 193-196.doi: 10.19982/j.issn.1000-6621.20210660

• 综述 • 上一篇    下一篇

宿主转录标志物GBP5DUSP3KLF2的研究进展

韩婷婷1, 陈秋奇1, 邓国防2()   

  1. 1广东医科大学第一临床医学院,湛江 524023
    2广东医科大学附属深圳市第三人民医院肺二科,深圳 518112
  • 收稿日期:2021-11-18 出版日期:2022-02-10 发布日期:2022-02-14
  • 通信作者: 邓国防 E-mail:jxxk1035@yeah.net
  • 基金资助:
    国家自然科学基金项目(82070016);深圳市第三人民医院院内课题(2021015)

The research progress of 3-gene host transcriptional biomarkers (GBP5, DUSP3 and KLF2)

HAN Ting-ting1, CHEN Qiu-qi1, DENG Guo-fang2()   

  1. 1The First Clinical School of Medicine, Guangdong Medical University, Zhanjiang 524023, China
    2The Second Department of Pulmonary Diseases, Shenzhen Third People’s Hospital Affiliated to the Guangdong Medical University, Shenzhen 518112, China
  • Received:2021-11-18 Online:2022-02-10 Published:2022-02-14
  • Contact: DENG Guo-fang E-mail:jxxk1035@yeah.net
  • Supported by:
    National Natural Science Foundation of China(82070016);Shenzhen Third People’s Hospital foundation(2021015)

摘要:

结核病依旧是全球特别是发展中国家重要的公共卫生问题,严重威胁着人类的健康,为实现世界卫生组织2035年“终止结核病”的目标,人们迫切需要新型、快速、准确、价格低廉的结核病诊断和监测治疗反应的技术。研究表明,基因宿主转录标志物鸟苷酸结合蛋白5(guanylate binding protein5,GBP5)、双特异性磷酸酶3(dual specificity phosphatase3,DUSP3)、Krüppel样转录因子2(Krüppel-like transcription factor2,KLF2)可改善结核病的临床诊断并用于结核病治疗监测。为更好地认识其临床意义,笔者从GBP5DUSP3KLF23基因宿主转录标志物的发现、发展、临床价值和局限性等方面进行综述,以供读者参考借鉴。

关键词: 结核, 鸟苷酸结合蛋白5, 双特异性磷酸酶3, Krüppel样转录因子2

Abstract:

Tuberculosis remains a major public health problem in the world. Especially in developing countries, there has a serious threat to human health. Further achieving the WHO’s goal of “End TB” by 2035, there urgently need new, fast, accurate and affordable detecting techniques for diagnosing TB and monitoring treatment responses. There have researches that shown to improve the tuberculosis clinical diagnosis and treatment monitoring with a 3-gene transcriptional biomarkers including guanylate binding protein5 (GBP5), dual specificity phosphatase3 (DUSP3) and Krüppel-like transcription factor2 (KLF2). To better understanding its clinical value, we have briefly summarized the finding, development, clinical importance and limitations of 3-gene host transcriptional biomarkers.

Key words: Tuberculosis, Guanylate binding protein5 (GBP5), Dual specificity phosphatase3 (DUSP3), Krüppel-like transcription factor2 (KLF2)

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